Abstract: Provided herein are methods and compositions that relate to, inter alia, CBL0137, a carbazole compound 1,1?-[9-[2-[(1-methylethyl)amino]ethyl]-9H-carbazole-3,6-diyl]bis-ethanone, useful for the treatment of various cancers, optionally in combination with various agents.
Abstract: The present invention relates to, inter alia, measuring of at least one component of the facilitates chromatin transcription complex (FACT) for evaluating a tumor, including, for example, determining the aggressiveness of a tumor and directing treatment.
Abstract: Compounds of the general structural formula (I) and (II) and use of the compounds and salts and hydrates thereof, as therapeutic agents are disclosed. Treatable diseases and conditions include cancers, inflammatory diseases and conditions, and immunodeficiency diseases. (I), (II).
Type:
Grant
Filed:
December 21, 2016
Date of Patent:
November 27, 2018
Assignee:
INCURON, INC.
Inventors:
John Tucker, Sergey Sviridov, Leonid Brodsky, Catherine Burkhart, Andrei Purmal, Katerina Gurova, Andrei Gudkov