Abstract: Human HL-60 lectin having an amino acid sequence different from other known animal lectins is disclosed. This is one member of a class of mammalian lectins extractable in lactose or detergent and specific for beta-D-galactosides (14-beta-gal lectin which contains at least one glycosylation site). Recombinant methods and materials for production of the mammalian 14-beta-gal lectins, especially HL-60 lectin, in a variety of hosts, and methods to utilize the resulting lectins are also described. Human HL-60 lectin is found in HL-60 cells and in placental tissue.
Type:
Grant
Filed:
August 5, 1994
Date of Patent:
December 24, 1996
Assignee:
Incyte Pharmaceutical Corporation
Inventors:
Glenn E. Nedwin, Timothy S. Bringman, Pierre-Oliver Couraud