Patents Assigned to Incyte Pharmaceuticals, Inc.
  • Construction of uni-directionally cloned cDNA libraries from messenger RNA for improved 3? end DNA sequencing
    Patent number: 6387624
    Abstract: Methods are provide for preparing cDNA corresponding to a mRNA. In the subject methods, a mRNA is first contacted with a mixture of primers under first strand cDNA synthesis conditions. The primer mixture contains primers that have at least 10 contiguous deoxythymidines, a double stranded restriction enzyme recognition sequence near one end and a non-polyA-complementary region near the other end, where the non-polyA-complementary region is -VV, -VTV, -VTTV, -VTTTV, and -VVVVV. The resultant cDNA is modified such that the polyT tail is substantially removed. The modified cDNA is then ligated into a vector. The subject methods find use in a variety of applications, and find particular use in the sequencing of DNA and in the synthesis of cDNA libraries.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: May 14, 2002
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Glenn K. Fu, Steven Starnes, Laura L. Stuve
  • Novel human selenium-binding protein
    Publication number: 20020042066
    Abstract: The present invention provides a human selenium-binding protein (HSEBP) and polynucleotides which identify and encode HSEBP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HSEBP and a method for producing HSEBP. The invention also provides for agonists and antibodies specifically binding HSEBP, and their use in the prevention and treatment of diseases associated with expression of HSEBP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HSEBP for the treatment of diseases associated with the expression of HSEBP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HSEBP.
    Type: Application
    Filed: April 24, 2001
    Publication date: April 11, 2002
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Phillip R. Hawkins
  • Novel human protein kinases
    Publication number: 20020042114
    Abstract: The present invention provides novel human protein kinases (HPK) and polynucleotides which identify and encode HPK. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPK. The invention also provides for pharmaceutical compositions comprising HPK or antagonists of HPK, and antibodies which specifically bind HPK. Additionally, the invention provides antisense molecules to HPK for treatment or prevention of diseases associated with abnormal expression of HPK.
    Type: Application
    Filed: March 15, 2001
    Publication date: April 11, 2002
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Janice Au-Young, Karl J. Guegler, Phillip R. Hawkins
  • Human extracellular matrix proteins
    Publication number: 20020038006
    Abstract: The invention provides two human extracellular matrix proteins (ECMP) and polynucleotides which identify and encode ECMP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of ECMP.
    Type: Application
    Filed: April 16, 2001
    Publication date: March 28, 2002
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Neil C. Corley, Karl J. Guegler
  • Novel tumorigenesis protein
    Publication number: 20020037518
    Abstract: The present invention provides a human tumorigenesis protein (HTAP) and polynucleotides which identify and encode HTAP. In addition, the invention provides expression vectors and host cells, agonists, antibodies, and antagonists. The invention also provides methods for producing HTAP and for treating or preventing disorders associated with the expression of HTAP.
    Type: Application
    Filed: May 4, 2001
    Publication date: March 28, 2002
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Surya K. Goli
  • Human glutathione peroxidase-6
    Publication number: 20020031506
    Abstract: The invention provides a human glutathione peroxidase (GPx6) and polynucleotides which identify and encode GPx6. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of GPx6.
    Type: Application
    Filed: March 16, 2001
    Publication date: March 14, 2002
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Neil C. Corley, Chandra Patterson
  • Mammalian phospholipase A2 nucleotide sequences, low molecular weight amino acid sequences encoded thereby, antisense sequences and nucleotide sequences having internal ribosome binding sites
    Patent number: 6352849
    Abstract: Novel mammalian phospholipase (PLA2) nucleotide sequences and low molecular weight (about 14 KD) amino acid sequences encoded thereby are disclosed. More particularly, a cloned human HPLA2 cDNA expressing HPLA2-10 and its cloned rat RPLA2 cDNA counterpart, expressing RPLA2-10, which are characterized as PLA2 Type IV, are disclosed. A second type of PLA2 cDNA, characterized as PLA2 Type III and exemplified by a rat PLA2 cDNA encoding RPLA2-8 and a partial human PLA2 nucleotide sequence encoding HPLA2-8, is disclosed. Expression of the cDNAs encode the two new types of PLA2 enzymes which have phospholipase activity. The novel PLA2s do not include disulfide bridges between cysteine amino acids 11 and 77 or elapid loops. However, the novel PLA2s may include amino acid COOH-terminal extensions which can vary in length.
    Type: Grant
    Filed: July 28, 1999
    Date of Patent: March 5, 2002
    Assignees: Incyte Pharmaceuticals, Inc.
    Inventors: Jay A. Tischfield, Jeffrey J. Seilhamer
  • Polynucleotides and polypeptides derived from corn seedling
    Publication number: 20020013958
    Abstract: The present invention provides purified, corn seedling-derived polynucleotides (cdps) which encode corn seedling-derived polypeptides (CDPs). The invention also provides for the use of cdps or their complements, oligonucleotides, or fragments in methods for determining altered gene expression, to recover regulatory elements, and to follow inheritance of desirable characteristics through hybrid breeding programs. The invention further provides for vectors and host cells containing cdps for the expression of CDPs. The invention additionally provides for (i) use of isolated and purified CDPs to induce antibodies and to screen libraries of compounds and (ii) use of anti-CDP antibodies in diagnostic assays.
    Type: Application
    Filed: August 6, 2001
    Publication date: January 31, 2002
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Raghunath V. Lalgudi, Laura Y. Ito, Bradley K. Sherman
  • Thyroid and pituitary membrane protein
    Publication number: 20020009778
    Abstract: The invention provides a human thyroid and pituitary membrane protein (TPMP) and polynucleotides which identify and encode TPMP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of TPMP.
    Type: Application
    Filed: May 7, 2001
    Publication date: January 24, 2002
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Preeti Lal, Neil C. Corley, Gina Gorgone
  • Cyclic GMP phosphodiesterase
    Publication number: 20020007046
    Abstract: The invention provides a human cyclic GMP phosphodiesterase (PDE9A) and polynucleotides which identify and encode PDE9A. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of PDE9A.
    Type: Application
    Filed: March 8, 2001
    Publication date: January 17, 2002
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Douglas A. Fisher, Douglas H. Gooding, David Gray Streeter
  • Human cytokines
    Publication number: 20020001827
    Abstract: The present invention provides novel human cytokines (designated individually as NHC-1 and NHC-2, and collectively as NHC) and polynucleotides which identify and encode NHC. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHC and a method for producing NHC. The invention also provides for use of NHC and agonists, antibodies, or antagonists specifically binding NHC, in the prevention and treatment of diseases associated with expression of NHC. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHC for the treatment of diseases associated with the expression of NHC. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHC.
    Type: Application
    Filed: February 12, 2001
    Publication date: January 3, 2002
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Phillip R. Hawkins, Lynn E. Murry, Surya K. Goli
  • Methods and compositions for producing full length cDNA libraries
    Patent number: 6326175
    Abstract: Methods and compositions are provided for producing full-length cDNA libraries. In the subject methods, full length first strand cDNAs are isolated using a fusion protein of an eIF-4E domain and an eIF-4G domain separated by a flexible linker. Also provided is the novel fusion protein employed in the subject methods, as well as nucleic acids encoding, and host cells capable of expressing, the same. Finally, kits for use in practicing the subject methods are provided. The subject invention finds use in a variety of applications in which full-length CDNA libraries are employed.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: December 4, 2001
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Karl Guegler, Ruoying Tan, Michael J. Rose
  • Novel subunits of NADH dehydrogenase
    Publication number: 20010041356
    Abstract: The present invention provides four NADH dehydrogenase subunits (designated individually as NDS-1, NDS-2, NDS-3, and NDS-4 and collectively as NDS) and polynucleotides which identify and encode NDS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NDS and a method for producing NDS. The invention also provides for use of NDS and agonists, antibodies, or antagonists specifically binding NDS, in the prevention and treatment of diseases associated with expression of NDS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NDS for the treatment of diseases associated with the expression of NDS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NDS.
    Type: Application
    Filed: November 29, 2000
    Publication date: November 15, 2001
    Applicant: Incyte Pharmaceuticals, Inc
    Inventors: Olga Bandman, Surya K. Goli, Jennifer L. Hillman
  • Database for storage and analysis of full-length sequences
    Patent number: 6303297
    Abstract: The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: October 16, 2001
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Steve E. Lincoln, Tod M. Klingler, Janice Au-Young, Y. Tom Tang, Richard D. Goold, Ingrid E. Akerblom, Jeffrey J. Seilhamer, Phillip R. Hawkins, Lynn E. Murry, Angelo M. Delegeane, Wendy B. Levine, Jennifer L. Hillman, Surya K. Goli, Christina M. Altus, Olga Bandman, Samuel T. LaBrie, Purvi Shah
  • Human membrane-spanning proteins
    Publication number: 20010025098
    Abstract: The invention provides a human membrane spanning proteins (MSPs) and polynucleotides which identify and encode MSPs. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of MSPs.
    Type: Application
    Filed: March 30, 2001
    Publication date: September 27, 2001
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Y. Tom Tang, Olga Bandman, Preeti Lal, Jennifer L. Hillman, Henry Yue, Neil C. Corley, Karl J. Guegler, Matthew R. Kaser, Mariah R. Baughn, Purvi Shah
  • Human peroxisomal thioesterase
    Publication number: 20010024786
    Abstract: The invention provides a human peroxisomal thioesterase (PxTE) and polynucleotides which identify and encode PxTE. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PxTE.
    Type: Application
    Filed: January 18, 2001
    Publication date: September 27, 2001
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Purvi Shah, Neil C. Corley
  • Autoantigen-like protein
    Publication number: 20010016648
    Abstract: ? The invention provides an autoantigen-like protein (AUTOP) and polynucleotides which identify and encode AUTOP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of AUTOP.
    Type: Application
    Filed: January 10, 2001
    Publication date: August 23, 2001
    Applicant: Incyte Pharmaceuticals, Inc,
    Inventors: Preeti Lal, Neil C. Corley, Y. Tom Tang
  • Human NADH dehydrogenase subunits
    Patent number: 6277572
    Abstract: The present invention provides a human NADH-D protein subunit (NDS) and polynucleotides which encode NDS. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of NDS.
    Type: Grant
    Filed: December 9, 1998
    Date of Patent: August 21, 2001
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Purvi Shah, Preeti Lal
  • Calcium-binding protein
    Publication number: 20010012831
    Abstract: The present invention provides a human calcium-binding protein (HCBP) and polynucleotides which identify and encode HCBP. The invention also provides expression vectors and host cells, agonists, antibodies, and antagonists. In addition, the invention provides methods for producing HCBP and for treating or preventing disorders associated with the expression of HCBP.
    Type: Application
    Filed: January 23, 2001
    Publication date: August 9, 2001
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Surya K. Goli
  • Extracellular adhesive proteins
    Publication number: 20010010913
    Abstract: The invention provides human extracellular adhesive proteins (EXADH) and polynucleotides which identify and encode EXADH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of EXADH.
    Type: Application
    Filed: December 22, 2000
    Publication date: August 2, 2001
    Applicant: Incyte Pharmaceuticals, Inc
    Inventors: Jennifer L. Hillman, Henry Yue, Neil C. Corley, Karl J. Guegler, Chandra Patterson