Abstract: The present disclosure provides pharmaceutical agents, including those of the formula: (I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents are also provided. The compounds may be used for the inhibition or antagonism of integrins ???? and/or ?5??. In some embodiments, the compounds provided herein exhibit reduced inhibitory or antagonistic activity of integrins ???3, ???5, ???6, ???8, and/or ?IIb?3.
Type:
Grant
Filed:
December 28, 2017
Date of Patent:
April 19, 2022
Assignees:
Saint Louis University, Indalo Therapeutics, Inc.
Inventors:
Peter G. Ruminski, David W. Griggs, Scott Seiwert
Abstract: The present disclosure provides pharmaceutical agents, including those of the formula: (I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents are also provided. The compounds may be used for the inhibition or antagonism of integrins ???1 and/or ?5?1. In some embodiments, the compounds provided herein exhibit reduced inhibitory or antagonistic activity of integrins ???3, ???5, ???6, ???8, and/or ?IIb?3.
Type:
Application
Filed:
June 27, 2019
Publication date:
September 16, 2021
Applicants:
Saint Louis University, Indalo Therapeutics, Inc.
Inventors:
Peter G. RUMINSKI, David W. GRIGGS, Scott SEIWERT