Patents Assigned to Indian Institute of Science Education and Research
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Patent number: 11945838Abstract: The present invention discloses a novel cost effective method for synthesis of protein/peptide amphiphiles irrespective of functional and structural classification of proteins useful in designing a vaccine candidate from antigenic protein. The protein modification of the present invention is universal and hence any protein/peptide can be converted into amphiphilic proteins/peptides.Type: GrantFiled: December 20, 2019Date of Patent: April 2, 2024Assignee: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCHInventors: Sandanaraj Selvaraj Britto, Mullapudi Mohan Reddy
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Patent number: 11879894Abstract: This invention discloses bi-functional photoactivable fluorescent lipid probes for proximity labelling-based identification of membrane-associated proteins, and synthesis thereof. The photoactivable fluorescent lipid probe include a lipid moiety, a fluorophore, and a photoactivable moiety; where the fluorophore and the photoactivable moiety are covalently attached to the lipid moiety.Type: GrantFiled: June 3, 2020Date of Patent: January 23, 2024Assignee: Indian Institute of Science Education and ResearchInventors: Gregor Jose, Thomas Pucadyil
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Patent number: 11872212Abstract: The invention provides non-centrosymmetric organic crystals which show exceptional self-healing properties. More particularly, the present invention provides non-centrosymmetric substituted imidazole and Dialkyl 4,4?-methylenebis(azanediyl)dibenzoate Crystals and a process for preparation thereof. These highly crystalline materials, when broken into pieces, can self-propel and re-join in the blink of an eye and repair themselves so precisely that they become indistinguishable from the undisturbed materials.Type: GrantFiled: July 26, 2022Date of Patent: January 16, 2024Assignee: Indian Institute of Science Education and Research (IISER) KolkataInventors: Chilla Malla Reddy, Surojit Bhunia, Rituparno Chowdhury, Ishita Ghosh
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Process for determining enzyme activity in a cell by activity-based reporter gene technology (ABRGT)
Patent number: 11834698Abstract: Methods and materials for specific imaging of active enzyme in a live or intact cell are disclosed. The enzyme of interest tagged to reporter protein (donor) is exogenously expressed in a cell. The conversion of proenzyme to active enzyme (containing reporter protein) is achieved upon applying an appropriate stimulus to the target cells. The activated enzyme is labelled with an activity-based probe carrying a fluorophore (acceptor). The covalent labelling of active enzyme by the activity-based probe creates a FRET pair which provides the opportunity to exquisitely image the function of an “active enzyme”. This method is used for specific imaging of the function of active caspase-3,-7,-8,-9 and cathepsin-B and also for profiling of inhibitors of caspases and cathepsin B.Type: GrantFiled: May 2, 2019Date of Patent: December 5, 2023Assignee: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCHInventors: Sandanaraj Selvaraj Britto, Punita Bathla -
Patent number: 11807884Abstract: The present invention discloses monodisperse protein-dendron conjugates that self-assemble to generation-dependent supramolecular protein assemblies of different size and surface charges. The invention further provides a process for synthesis of protein-dendron conjugates containing hydrophobic dendron of different generations.Type: GrantFiled: December 8, 2018Date of Patent: November 7, 2023Assignee: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCHInventors: Sandanaraj Selvaraj Britto, Pavankumar Janardhan Bhandari, Mullapudi Mohan Reddy
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Patent number: 11795468Abstract: The present invention relates to a nucleic acid construct. The nucleic acid construct includes a nucleic acid molecule configured to silence or reduce the expression of StBEL11 and/or StBEL29 and variants thereof, a 5? DNA promoter sequence, and a 3? terminator sequence, where the first nucleic acid molecule, the promoter sequence, and the terminator sequence are operatively coupled to permit transcription of the first nucleic acid molecule. The present invention is also directed to vectors, host cells, transgenic plants, and transgenic plant seeds, as well as non-transgenic mutant plants, and methods for altering tuber yield in a plant.Type: GrantFiled: January 11, 2019Date of Patent: October 24, 2023Assignees: Iowa State University Research Foundation, Inc., Indian Institute of Science Education and Research (IISER)Inventors: David J. Hannapel, Anjan K. Banerjee
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Publication number: 20230193469Abstract: The present disclosure relates to a patternable process for coating functional and adherent graphene-like carbon on multiple substrate types using CO2 laser-induced photothermal pyrolysis in scanning mode. The poly furfuryl alcohol (PFA) synthesised via low-temperature polymerisation of furfuryl alcohol precursor without any additives was used to form graphene-like carbon material.Type: ApplicationFiled: December 20, 2022Publication date: June 22, 2023Applicants: Indian Institute of Science Education and Research, TCG CENTRES FOR RESEARCH AND EDUCATION IN SCIENCE AND TECHNOLOGYInventors: Minal Wable, Mohammad Furquan, Abhik Banerjee, Satishchandra Ogale
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Publication number: 20220298541Abstract: The present disclosure relates to an assay for determining drug-target engagement in real-time. Specifically, the present disclosure provides a method for determining drug candidate-target interaction in real-time in living systems using Activity-based Reporter Gene Technology-Bioluminescence Resonance Energy Transfer (AbRGT-BRET) based assay. The said assay is useful for High Throughput Screening of compounds to a specific target.Type: ApplicationFiled: March 18, 2022Publication date: September 22, 2022Applicant: Indian Institute of Science Education and ResearchInventors: Britto S. SANDANARAJ, Punita BATHLA, Abhijit DE, Aaiyas MUJAWAR
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Publication number: 20220204554Abstract: The invention pertains to the method of N-terminus Glycine tagged metal-free protein purification by selective labeling of N-terminus Gly containing proteins, its capture, and release through modified resin under mild operating conditions. The selective labeling of N-terminus Glycine enables the formation of an aminoalcohol. The invention is for selective tagging of N-Gly in a protein. The invention is for separation of immobilised N-terminus glycine proteins from the functionalised resin under mild aqueous physiological conditions by C—C bond dissociation with additive, in which the additive enables the resonance-assisted electron density (RED) polarization to facilitate C—C bond dissociation. The invention provides the N-Gly specific installation of a probe in a protein within cell lysate. The invention covers the special aldehydes, including its on-resin derivative, for the given purpose.Type: ApplicationFiled: April 17, 2020Publication date: June 30, 2022Applicant: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH BHOPALInventor: Vishal RAI
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Patent number: 11173212Abstract: The present invention discloses stimuli-sensitive protein conjugate which can make supramolecular protein assemblies and methods for using the same. The present invention provides simple and rational process for construction of said stimuli-sensitive spherical protein assemblies through supramolecular chemical strategy.Type: GrantFiled: September 28, 2018Date of Patent: November 16, 2021Assignee: Indian Institute of Science Education and ResearchInventors: Sandanaraj Selvaraj Britto, Pavankumar Janardhan Bhandari, Mullapudi Mohan Reddy
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Patent number: 11149058Abstract: A multifunctional chemical agents comprising functional agents Fn1, Fn2 and linkers, for the linchpin directed (LDM), protein directed (PDPM) modifications of proteins, and Fn1 accelerated kinetic labeling by Fn2.Type: GrantFiled: November 17, 2016Date of Patent: October 19, 2021Assignees: Department of Biotechnology, Indian Institute of Science Education and Research BhopalInventors: Vishal Rai, Srinivasa Rao Adusumalli
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Publication number: 20210310949Abstract: Disclosed herein is a novel phenomenon to create a nano-confined, dopant-free, electron spin-dependent fluorescence (SDF) in spider silk by fundamentally transforming its local molecular structure with femtosecond-pulses (206), having fluence below an ablation threshold. Electron-spin dependence of the fluorescent patterns created on the silk sample are confirmed by measuring the fluorescence intensity at different microwave frequencies. The fluorescent intensity exhibits microwave magnetic resonances at 2.88 GHz and 1.44 GHz at room-temperature. The SDF in laser-transformed silk can thereby enable a new-class of tough yet elastic silk-based quantum sensor and hybrid nano-mechanical ultrasensitive cantilevers on a micro-chip.Type: ApplicationFiled: March 31, 2021Publication date: October 7, 2021Applicant: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCHInventors: Kamal Priya SINGH, Mehra Singh SIDHU, Biswajit PANDA
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Publication number: 20210163526Abstract: A multifunctional chemical agents comprising functional agents Fn1, Fn2 and linkers, for the linchpin directed (LDM), protein directed (PDPM) modifications of proteins, and Fn1 accelerated kinetic labeling by Fn2.Type: ApplicationFiled: November 17, 2016Publication date: June 3, 2021Applicants: Department of Biotechnology, Indian Institute of Science Education and ResearchInventors: Vishal RAI, Srinivasa Rao ADUSUMALLI
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Patent number: 10493558Abstract: The present invention relates to nanoprocessing and heterostructuring of silk. It has been shown that few-cycle femtosecond pulses are ideal for controlled nanoprocessing and heterostructuring of silk in air. Two qualitatively different responses, ablation and bulging, were observed for high and low laser fluence, respectively. Using this approach, new classes of silk-based functional topological microstructures and heterostructures which can be optically propelled in air as well as on fluids remotely with good control have been fabricated.Type: GrantFiled: August 14, 2018Date of Patent: December 3, 2019Assignee: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCHInventors: Kamal Priya Singh, Mehra Singh Sidhu, Bhupesh Kumar
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Patent number: 10301727Abstract: The present invention discloses porous covalent organic frameworks (COF) supported noble metal-free nanoparticles which are useful as electrocatalysts for a water splitting system, and to the process for preparation of such electrocatalysts. The covalent organic frameworks (COF) supported noble metal-free nanoparticles have general formula (I): COF_AxBy(M)n??(Formula I) wherein COF is selected from a Tris (4-formylphenyl)amine terephthaldehyde polymer or a benzimidazole-phloroglucinol polymer; ‘A’ and ‘B’ each independently represent a transition metal selected from the group consisting of Ni, Co, Fe, Mn, Zn, and mixtures thereof; or ‘A’ and ‘B’ together represent a transition metal selected from the group consisting of Ni, Co, Fe, Mn, Zn, and mixtures thereof; ‘M’ represents hydroxide or a nitride ion; ‘x’ and ‘y’ represent the weight % of the metal loadings; or a ratio of x:y is between 0:1 and 1:0; and ‘n’ is an integer 1 or 2 or 3.Type: GrantFiled: November 10, 2016Date of Patent: May 28, 2019Assignee: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCHInventors: Vaidhyanathan Ramanathan, Dinesh Mullangi, Shyamapada Nandi
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Publication number: 20190085020Abstract: A multifunctional chemical agents comprising functional agents Fn1, Fn2 and linkers, for the linchpin directed (LDM), protein directed (PDPM) modifications of proteins, and Fn1 accelerated kinetic labeling by Fn2.Type: ApplicationFiled: November 17, 2016Publication date: March 21, 2019Applicants: Department of Biotechnology, Indian Institute of Science Education and ResearchInventors: Vishal RAI, Srinivasa Rao ADUSUMALLI
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Patent number: 10188136Abstract: The present invention discloses hydrophobin mimics of formula (I) comprising a protein head group, hydrophilic linker and hydrophobic tail and to a process for synthesis of library of hydrophobin mimics thereof. The hydrophobin mimics of the present invention self-assemble to form protein nanoparticles/nanocontainer either alone or in a specified chemical environment. The hydrophobin mimics (I) of the present invention find application in area of bio-nanotechnology.Type: GrantFiled: February 16, 2017Date of Patent: January 29, 2019Assignee: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCHInventors: Sandanaraj Selvaraj Britto, Mullapudi Mohan Reddy, Pavankumar Janardhan Bhandari, Kasuladevu Jagannadha Rao
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Publication number: 20180354066Abstract: The present invention relates to nanoprocessing and heterostructuring of silk. It has been shown that few-cycle femtosecond pulses are ideal for controlled nanoprocessing and heterostructuring of silk in air. Two qualitatively different responses, ablation and bulging, were observed for high and low laser fluence, respectively. Using this approach, new classes of silk-based functional topological microstructures and heterostructures which can be optically propelled in air as well as on fluids remotely with good control have been fabricated.Type: ApplicationFiled: August 14, 2018Publication date: December 13, 2018Applicant: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCHInventors: Kamal Priya SINGH, Mehra Singh Sidhu, Bhupesh Kumar
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Patent number: 10131922Abstract: The invention is for an increased isoprenoid production by carotenoid optimization in an expression system and the carotegenic gene for optimization may be geranylgeranyl diphosphate synthase (GGPPS), phytoene synthase (PSY1), conserved CRTI or mutated CRT1A393T, BT1 of S. cerevisae. The carotogenic gene from red yeast which includes Rhodosporidium spp. Rhodotorula spp, Sporidiobolus spp., Leucosporidium spp., Sporobolomyes spp. is selected.Type: GrantFiled: March 10, 2016Date of Patent: November 20, 2018Assignee: Indian Institute of Science Education and ResearchInventors: Manisha Wadhwa, Anand Kumar Bachhawat
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Publication number: 20170029962Abstract: The invention discloses a method for the synthesis of monodispersed luminescent quantum dots of transition metal dichalcogenides (TMDC), single- or few-layered, using a single-step electrochemical exfoliation that involves dilute ionic liquid and water. The method disclosed helps to obtain nanoclusters of TMDC of desired size including small sizes ranging up to 6 nm, by varying the concentration of the electrolyte and the applied DC voltage. The invention further discloses a method by which mono- or few-layered luminescent transition metal dichalcogenides can be directly deposited onto conducting substrates in a uniform manner. The monodispersed single- or few-layered luminescent TMDC and electro-deposited substrates exhibit improved electronic conductivity and new active sites, making them suitable as high-performance electrocatalysts in hydrogen evolution reactions in solar water-splitting applications and also as electrodes for solar cell applications.Type: ApplicationFiled: August 1, 2016Publication date: February 2, 2017Applicant: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH , THIRUVANANTHAPURAM (IISER-TVM)Inventors: Shaijumon Mancheri Manikoth, Dijo Damien, Deepesh Gopalakrishnan