Abstract: The present invention relates to method of using spectroscopy for real time measuring of concentration of desired product and using measured data for monitoring and control of chromatography. It develops a method and system for measuring real-time concentration of clarified harvest and that of flow through of loading step of the chromatography and using measured data for determining breakthrough in real-time. The two modes of operation are used viz. first mode (Part A) uses a single near infrared spectroscopy (NIR) flow cell prior to the continuous chromatography column to ensure optimal loading in each cycle based on dynamic binding capacity studies carried out previously with the desired Protein A resin and second mode (Part B) uses two near infrared spectroscopy (NIR) flow cells, one before and one after the column, to detect the breakthrough curve (from 1% breakthrough onwards).

Abstract: An aspect of the present disclosure relates to a process for preparing a composite hydroalkylation catalyst including: (a) effecting impregnation of a hydrogenation metal on an inorganic oxide to form a metal impregnated inorganic oxide; (b) effecting calcination of the metal impregnated inorganic oxide to obtain a calcined metal impregnated inorganic oxide; (c) preparing a composite mixture comprising a molecular sieve, the calcined metal impregnated inorganic oxide and a binder; (d) preparing an extruded catalyst; and (e) effecting calcination of the extruded catalyst to obtain the composite hydroalkylation catalyst. The composite hydroalkylation catalyst prepared using this process affords dramatic improvement in conversion of mononuclear aromatic hydrocarbon and the yield of the hydroalkyled mononuclear aromatic hydrocarbon (e.g. CHB).

Abstract: In the present invention, a method for searching multilingual keywords in mixlingual speech corpus is proposed. This method is capable of searching audio as well as text keywords. The capability of audio search enables it to search out-of-vocabulary (OOV) words. The capability of searching text keywords enables it to perform semantic search. An advanced application of searching keyword translations in mixlingual speech corpus is also possible within posteriorgram framework with this system. Also, a technique for combining information from text and audio keywords is given which further enhances the search performance. This system is based on multiple posteriorgrams based on articulatory classes trained with multiple languages.

Abstract: The present disclosure relates to a formulation including: a) a dendron of Formula I; b) at least one bio-therapeutic; c) at least one buffer; and d) at least one salt, wherein the bio-therapeutic to dendron molar ratio is in the range of 1:0.5-1:3. The dendron stabilizes the bio-therapeutic in the formulation at a temperature of up to 55° C.

Abstract: The disclosure describes composite fibers reinforced with inorganic nanostructures of high aspect ratio with homogeneous dispersion and alignment along the fiber axis and a process for producing said composite fibers. A composite fiber comprising an array of inorganic nanowires embedded in a polymer matrix. The nanowires have a diameter <100 nm and high aspect ratio of at least 5 with homogenous dispersion and polymer chains of the polymer matrix and the nanowires are oriented along the fiber axis. The nanowire wt % in the composite fiber is in the range of 0.01 to 2 wt %. The inorganic nanowires are non conducting and include at least one of ZnO, or aluminosilicate clay tubes.

Abstract: A method, apparatus and system required to realize an optimization opportunity are disclosed. If an expression involves unsequenced evaluations involving side-effects and optionally references, then the expression is translated into optimized code that may involve optimized register usage, or optimized use of the underlying vectorization hardware. An alias-analysis logic is able to identify must-not-alias relationships through such expression tree structures. These must-not-alias relationships are helpful not just in optimizing the performance of that particular expression (from which these must-not-alias relationships were derived) but also in the performance of any other surrounding program statements that access the state elements participating in these must-not-alias relationships.

Abstract: An exoskeleton device for rehabilitation of distal joints of an upper limb of a patient is described. The exoskeleton device includes a multi-bar linkage and a first platform to support fingers of the patient. The exoskeleton device includes a second platform to support a palm of the patient. The first platform and the second platform are coupled to the multi-bar linkage. The exoskeleton device also includes a transmission unit to drive the multi-bar linkage to move the first platform and the second platform to provide flexion and extension of the distal joints of the upper limb of the patient. In addition, the exoskeleton device includes an armrest and a fastening mechanism to fasten a forearm of the patient.

Abstract: A process for decomposition of sulfuric acid, particularly a process for catalytically decomposing sulfuric acid is used to obtain sulfur dioxide therefrom. Catalysts are used for improving the dissociation efficiency by lowering the activation energy barrier for the reaction.

Abstract: One or more systems and methods for identifying one or more passive optical identifier tag from a plurality of passive optical identifier tags is provided. The method includes emitting light from a light source device. Further, the method includes transmitting, by said plurality of passive optical identifier tags, reflected light to a receiver. The method further includes reflecting, by the plurality of passive optical identifier tags, the emitted light with its unique set of wavelengths, said set of wavelengths being inferred by the corresponding reflection sequence.

Abstract: The present invention relates to novel immobilized nanoflowers made of Transglutaminase (TGase), a method for their synthesis and applications thereof. The Transglutaminase nanoflowers of the present invention are catalytically more active without mass transfer limitation, stable and reusable, wherein the overall flower is in the nano-range, is homo-dispersed and small-sized, and wherein Transglutaminase functions both as a cross-linking enzyme and as a seeding template.

Abstract: The present invention relates to a nanocarrier peptide sequence (SEQ ID NO: 6 KXPXXXXA/V/GXGNXX; wherein X is selected from amino acid R, K, A or H. The present invention also relates to the method for cellular delivery, by implementing the steps of: complexation of a peptide nanocarrier sequence: KXPXXXXA/V/GXGNXX; where X is selected from amino acid R,K,A and H having SEQ ID NO: 6 with a macromolecule to obtain a complex; and administering the complex to a targeted mammalian or plant cell or tissue.

Abstract: Examples of image sensors are described herein. In an example, an image sensor may comprise an array of hybrid pixels, where each hybrid pixel includes light sensing unit and a non-volatile memory component coupled to the light sensing unit. The light sensing unit comprises a light detecting element and a charge to voltage conversion unit. The charge to voltage conversion unit is to provide an output pixel signal (VPD), based on photo-electrons generated by the light detecting element. Further, the non-volatile component when calibrated to an initial resistance state is to compress the output pixel signal (VPD) during exposure.

Abstract: Described herein is a surge tank based system to control surge tanks in a manufacturing train. The system includes data acquisition unit, data normalization unit, deviation identification and handling unit and an real time execution of control action from centralized computer in a manufacturing process unit, wherein said manufacturing unit includes an integrated system which incorporates a plurality of pumps, surge tanks, and weighing balances, and other unit operations alongside the normal unit operations of production of output product.

Abstract: A method of detecting the presence of SARS-CoV-2 using oligonucleotide primer pairs is disclosed. Oligonucleotide primer pairs for the detection of SARS-CoV-2 using polymerase chain reaction (PCR)-based methods are also disclosed. Further, biomarkers and probes for SARS-CoV-2 detection are disclosed. The disclosure also relates to the identification and isolation of biomarkers for use as probes for the detection of SARS-CoV-2 and further use of the biomarkers as a target for the development of drug targets and therapeutics for SARS-CoV-2.

Abstract: The present invention relates to an ionic liquid based support of Formula-I: wherein: X+ is a heteroatom containing cationic part; W is a halogen containing polymeric solid support; n is an integer in the range of 2 to 8; Y is a hydrophobic anion; R is selected from CO—Z or Z; Z is selected from the group consisting of —Cl, —Br, —OH, —O-Alkyl and combinations thereof. The present invention also relates to a process for preparation of said ionic liquid based support used for di, oligo or polypeptide manufacture.

Abstract: The present invention relates generally to a non-invasive device for monitoring blood pressure using principle of applanation tonometry. A novel device for measuring pressure pulse comprises a differential screw mechanism, a sensor module connected to the screw mechanism, and an overall enclosure housing the sensor module and the differential screw mechanism in one unit. A pair of straps is attached to the enclosure, wherein said straps as a flex lock brace through a hinge to change the angle of extension of the wrist as required. The multi component sensor module comprises of a snap-fit enclosure, which houses a tactile-based force sensitive resistor, and a mechanism to transmit the forces from the artery. The force transmission mechanism comprises of a gel layer and a gel head. The differential screw mechanism ensures precise hold down pressure in multiple stages via screwing and unscrewing steps to accurately measure the blood pressure.

Abstract: The present invention relates to different liquid distributors for monolith in multiphase applications. The present invention more particularly relates to distributor devices in the form of a single injection and multiple injection pipe distributors; shower head distributor comprising a plurality of holes for plunging liquid; a packing of spherical particles with a pre-distributor to split the liquid into manifold streams, before entry into the monolith bed. The present invention provides liquid distributors for monolith in multiphase applications providing improved liquid distribution into the monolith bed resulting in uniform fluid flow in each channel so as to make maximum use of the catalyst surface area.

Abstract: In wireless system, radio frequency (RF) energy harvesting addresses the problem of limited battery lifetime in wireless nodes. In this invention, a wireless system for improving performance and prolonging battery life time of node, a battery assisted relay (2) framework is introduced. In this battery assisted relay framework, the energy harvested (EH) relay (2) augments the harvested energy with energy drawn from the battery (10) so as to prolong the battery life.

Abstract: Approaches for classifying training samples with minimal error in a neural network using a low complexity neural network classifier, are described. In one example, for the neural network, an upper bound on the Vapnik-Chervonenkis (VC) dimension is determined. Thereafter, an empirical error function corresponding to the neural network is determined. A modified error function based on the upper bound on the VC dimension and the empirical error function is generated, and used for training the neural network.

Abstract: The present subject matter describes system (100) for magnetic enrichment of magnetically marked analytes. The system has capture chip (102) comprising a sample chamber (104) for holding sample having magnetically marked analytes, and a recovery chamber (106) connected to the sample chamber by a channel (202). The volume of recovery chamber is smaller than volume of sample chamber (104). The system has magnetic arrangement (108) comprising a set of magnets (110) in which each two adjacent magnets have opposite polarities facing sample chamber. Set of magnets has dimensions that at least conform to coverage area of sample chamber. The magnetic arrangement also has at least one recovery magnet (112) having dimensions conforming to coverage area of recovery chamber and on alignment, the at least one recovery magnet (112) is at a distance farthest away from the recovery chamber. The system has a linear positioner (114) for moving the magnetic arrangement.