Patents Assigned to Indiana Univeresity Researc and Technology Corporation
  • Lipidated amide-based insulin prodrugs
    Patent number: 10385107
    Abstract: Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half-lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: August 20, 2019
    Assignee: Indiana Univeresity Researc and Technology Corporation
    Inventors: Richard D. Dimarchi, Binbin Kou, Fa Zhang, John P. Mayer