Patents Assigned to Indiana University Research and Technology Coporation
  • PEPTIDES THAT MODULATE THE EFFECT OF THE CRMP: NEUROFIBROMIN COMPLEX ON SYNAPTIC TRANSMISSION
    Publication number: 20180117114
    Abstract: The present disclosure relates generally to materials and methods for studying and treating neurofibromatosis type 1 (NF1) by modulating the interaction of CRMP-2 and neurofibromin. Some embodiments relates to newly synthesized polypeptides or a pharmaceutically acceptable salt thereof. Other embodiments relate to methods of treating a patient by providing at least one polypeptide. Another embodiment relates to a kit comprising at least one polypeptide.
    Type: Application
    Filed: March 25, 2016
    Publication date: May 3, 2018
    Applicant: Indiana University Research and Technology Coporation
    Inventor: Rajesh Khanna
  • TARGETING cGMP-RELATED PHOSPHODIESTERASES TO REDUCE CYST FORMATION IN CYSTIC KIDNEY DISEASE, AND RELATED MATERIALS AND METHODS
    Publication number: 20180078559
    Abstract: Described herein is the identification of cGMP-specific phosphodiesterase upregulation in cystic kidney diseases. Also described is the use of cGMP-specific phosphodiesterase inhibitors for preventing the progression and/or treatment of cystic kidney diseases. Other aspects described provide medicaments for preventing the progression and/or treating cystic kidney diseases, and methods of diagnosing cystic kidney disease.
    Type: Application
    Filed: March 14, 2016
    Publication date: March 22, 2018
    Applicant: Indiana University Research and Technology Coporation
    Inventors: Robert Bacallao, James A. Glazier, Sherry G. Clendenon, Rita Maria Cunha De Almeida