Abstract: Provided herein are trisubstituted methyl alcohols, preferably pH indicators that are substituted with optionally substituted aryl and or optionally substituted heteroaryl groups, and optionally include one or more polymerizable substituents.
Type:
Grant
Filed:
December 14, 2012
Date of Patent:
August 25, 2015
Assignee:
Indicator Systems International, Inc.
Inventors:
Gerald F. Swiss, Photon Rao, Ram W. Sabnis
Abstract: This invention relates to contact lenses comprising pH indicating moieties useful for determining the presence or absence of active bacterial infections wherein said pH indicator is entrapped in the lens. Other aspects relate to contact lenses comprising pH indicating moieties useful for determining the presence or absence of active bacterial infections and a biodegradable coating with a biocompatible colorant entrapped within the coating useful for determining the usable lifespan of the contact lens. Other aspects relate to methods of using such contact lenses.
Abstract: Polymeric indicators are provided for visually monitoring, detecting, and/or determining the presence of metabolic byproducts from harmful or potentially harmful microorganisms.
Abstract: Methods, devices, and kits are provided herein for the accurate and rapid detection of disease causing microbes in a sample by the detection of microbial components of which correlate to the presence of the microbe. Kits include a first binding agent operatively coupled to an immobilized support; and a second binding agent operatively coupled to one or more pH indicating moieties wherein the first and second binding agents bind with sufficient specificity to the microbial component to permit detection of that component which correlates to the presence of the microbe in the sample.
Abstract: Provided herein are trisubstituted methyl alcohols, preferably pH indicators that are substituted with optionally substituted aryl and or optionally substituted heteroaryl groups, and optionally include one or more polymerizable substituents.
Abstract: Polymeric indicator films and pH indicating wraps are provided for visually monitoring, detecting, and/or determining the presence of metabolic byproducts from harmful or potentially harmful microorganisms. Also provided are methods of use and preparation of the polymeric indicator films.
Type:
Grant
Filed:
January 25, 2010
Date of Patent:
April 23, 2013
Assignee:
Indicator Systems International, Inc.
Inventors:
Joel R. Gorski, Jon Booher, Ram W. Sabnis