Abstract: Methods for assessing the quality of a tissue sample. In some aspects, methods are provided for determine the time that a biological sample has been exposed to cold ischemia condition by measuring the expression level of an mRNA and/or a phosphoprotein.

Abstract: The present invention is directed to a method for detecting colorectal adenoma and/or colorectal carcinoma comprising the steps: a) providing an isolated sample material which has been taken from an individual, b) determining the level of an endoplasmin fragment or a derivative thereof in said isolated sample material, c) comparing the determined level of an endoplasmin fragment or a derivative thereof with one or more reference values. The invention is further directed to a method for discriminating between colorectal adenoma and colorectal carcinoma as well as to a method for monitoring the development and/or course of colorectal adenoma and/or colorectal carcinoma and/or the treatment of colorectal adenoma and/or colorectal carcinoma. Moreover, the invention is directed to a test system and an array for use in these methods. Furthermore, the invention is directed to the use of an endoplasmin fragment as a biomarker for a detection of colorectal adenoma and/or colorectal carcinoma in an individual.

Abstract: The present invention is directed to a method for detecting colorectal adenoma and/or colorectal carcinoma comprising the steps: a) providing an isolated sample material which has been taken from an individual, b) determining the level of C3a or a derivative thereof in said isolated sample material, c) comparing the determined level of C3a or a derivative thereof with one or more reference values. The invention is further directed to a method for discriminating between colorectal adenoma and colorectal carcinoma as well as to a method for monitoring the course of colorectal adenoma and/or colorectal carcinoma and/or the treatment of colorectal adenoma and/or colorectal carcinoma. Moreover, the invention is directed to a test system and an array for use in these methods. Furthermore, the invention is directed to the use of C3a as a biomarker for a detection of colorectal adenoma and/or colorectal carcinoma in an individual.