Abstract: The embodiments herein provide an improved Zymotis solid-state bioreactor and its operation for cultivation of microorganisms aseptically. In one embodiment, a bioreactor has two compartments containing three cooling plates. These plates have internal baffles instead of cooling tubes. The bioreactor has temperature sensors are loaded at different heights of the outer cooling plates for recoding and monitoring bed temperature during fermentation. Short space between two cooling plates with suitable material construction permits metabolic heat removal by conduction. The distance between two compartments is adjustable manually to achieve the best width. The product is extracted and harvested in the bioreactor using a trickle solvent. All of the on-line data are monitored on screen and recorded in the computer. Microorganisms are cultivated in such a manner that the bioreactor carries out all steps for cultivating microorganisms in an aseptic environment.