Patents Assigned to Industriale Chimica S.R.L.
  • Process for preparing budesonide
    Patent number: 8119793
    Abstract: A process is described for preparing budesonide which comprises the steps of: a) preparing an aqueous hydrochloric acid solution; b) reacting 16?-hydroxyprednisolone and butyraldehyde within the solution prepared in step a), in an inert atmosphere; c) quenching the reaction of step b) with water. The process of the invention enables the ratio between the A and B epimers of budesonide to be controlled.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: February 21, 2012
    Assignee: Industriale Chimica S.r.L.
    Inventors: Roberto Lenna, Maurizio Montoro
  • Process for the preparation of 21-hydroxy steroids with control of the epimeric distribution at the C-21 position
    Patent number: 7868194
    Abstract: A process is described for preparing, exclusively by chemical way, 21-hydroxy steroids having progestinic activity, said process having a high stereochemical control at C-21 position.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: January 11, 2011
    Assignee: Industriale Chimica S.R.L.
    Inventors: Francesca Costantino, Roberto Lenna, Maria Julieta Comin, Javier Ramirez, Juan Bautista Rodriguez
  • Process for the preparation of drospirenone
    Patent number: 7585971
    Abstract: A process is described for preparing drospirenone, a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for the preparation of pharmaceutical compositions with contraceptive action, starting from 5,6?-epoxy-7?-hydroxy-15?,16?-methylene-3?-pivaloyloxy-5?-androstan-17-one.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: September 8, 2009
    Assignee: Industriale Chimica S.R.L.
    Inventors: Francesca Costantino, Roberto Lenna, Silvia Piuri
  • Process for the Preparation of 21-Hydroxy Steroids with Control of the Epimeric Distribution at the C-21 Position
    Publication number: 20080114180
    Abstract: A process is described for preparing, exclusively by chemical way, 21-hydroxy steroids having progestinic activity, said process having a high stereochemical control at C-21 position.
    Type: Application
    Filed: October 20, 2005
    Publication date: May 15, 2008
    Applicant: INDUSTRIALE CHIMICA S.R.L.
    Inventors: Francesca Costantino, Roberto Lenna, Maria Julieta Comin, Javier Ramirez, Juan Bautista Rodriguez
  • Process for the preparation of gestodene
    Patent number: 5719300
    Abstract: Disclosed is a process for the preparation of Gestodene (formula I) from (-)estra-1,3,5(10),8-tetraen-3-methoxy-18-methyl-17.beta.-hydroxy.
    Type: Grant
    Filed: August 16, 1995
    Date of Patent: February 17, 1998
    Assignee: Industriale Chimica S.R.L.
    Inventors: Rino Prendin, Silvio Pirovano