Abstract: A mixed metal compound for pharmaceutical use is free from aluminium and has a phosphate binding capacity of at least 30%, by weight of the total weight of phosphate present, over a pH range of from 2-8. The compound is especially useful for treatment of hyperphosphataemia. The metals are preferably iron (III) and at least one of calcium, magnesium, lanthanum and cerium. A metal sulphate for pharmaceutical use is selected from at least one of calcium, lanthanum and cerium sulphate compounds and has a phosphate binding capacity of at least 30% by weight of the total phosphate present, over a pH range from 2-8.
Type:
Application
Filed:
July 1, 2010
Publication date:
January 20, 2011
Applicant:
INEOS HEALTHCARE LIMITED
Inventors:
Norman B. Roberts, Maurice Webb, Benjamin J. Rankin
Abstract: A mixed metal compound for pharmaceutical use is free from aluminium and has a phosphate binding capacity of at least 30%, by weight of the total weight of phosphate present, over a pH range of from 2-8. The compound is especially useful for treatment of hyperphosphataemia. The metals are preferably iron (III) and at least one of calcium, magnesium, lanthanum and cerium. A metal sulphate for pharmaceutical use is selected from at least one of calcium, lanthanum and cerium sulphate compounds and has a phosphate binding capacity of at least 30% by weight of the total phosphate present, over a pH range from 2-8.
Type:
Grant
Filed:
July 10, 2003
Date of Patent:
September 21, 2010
Assignee:
INEOS Healthcare Limited
Inventors:
Norman B. Roberts, Maurice Webb, Benjamin J. Rankin
Abstract: A substance for use as a medicament, comprises a solid mixed metal compound of formula (I): MII1?aMIIIaObAn?c.zH2O (I) where MII is at least one bivalent metal: MIII bis at least one trivalent metal; An? is at least one n-valent anion; 2+a=2b+?cn; and ?cn<0.9a. The substance may be made by heating at a temperature of from 200° C. to 600° C. preferably from 250° C. to 500° C. of a substance comprising a compound of formula (II): MII1?xMIIIx(OH)2An?y.mH2O (II) where MII is at least one bivalent metal; MIII is at least one trivalent metal; An? is at least one n-valent anion; x=?yn 0<x?0.5, 0<y?1 and 0<m?10.
Type:
Application
Filed:
February 6, 2006
Publication date:
August 28, 2008
Applicant:
Ineos Healthcare Limited
Inventors:
Maurice Sydney Newton, Nigel Peter Rhodes, Alexi John Toft