Patents Assigned to InfaCare Pharmaceutical Corporation
-
Patent number: 10273255Abstract: Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.Type: GrantFiled: January 11, 2018Date of Patent: April 30, 2019Assignee: INFACARE PHARMACEUTICAL CORPORATIONInventors: George S. Drummond, Robert Caroselli, Keith A. Cooke, Daniel Levin, David G. Roe, Christopher P. Boucher
-
Patent number: 9902745Abstract: Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.Type: GrantFiled: November 4, 2016Date of Patent: February 27, 2018Assignee: INFACARE PHARMACEUTICAL CORPORATIONInventors: George S. Drummond, Robert Caroselli, Keith A. Cooke, Daniel Levin, David G. Roe, Christopher P. Boucher
-
Patent number: 9688705Abstract: Embodiments describe methods of synthesizing metal mesoporphyrin compounds. In embodiments, a metal mesoporphyrin compound may be formed by hemin transmetallation and subsequent hydrogenation of the tin protoporphyrin IX to form a metal mesoporphyrin. In other embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a protoporphyrin methyl ester from hemin and converting the protoporphyrin methyl ester intermediate to a metal mesoporphyrin compound through metal insertion and hydrogenation. In other embodiments, a metal mesoporphyrin compound may be formed from hemin by a hydrogen-free hydrogenation method to form a mesoporphyrin IX intermediate followed by metal insertion and hydrogenation. In embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a mesoporphyrin IX dihydrochloride intermediate compound and converting the mesoporphyrin IX intermediate to a metal mesoporphyrin compound through metal insertion.Type: GrantFiled: October 5, 2015Date of Patent: June 27, 2017Assignee: INFACARE PHARMACEUTICAL CORPORATIONInventors: Christopher P. Boucher, David Roe
-
Patent number: 9517239Abstract: Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.Type: GrantFiled: July 8, 2015Date of Patent: December 13, 2016Assignee: Infacare Pharmaceutical CorporationInventors: George S. Drummond, Robert Caroselli, Keith A. Cooke, Daniel Levin, David G. Roe, Christopher P. Boucher
-
Patent number: 9181285Abstract: Embodiments describe methods of synthesizing metal mesoporphyrin compounds. In embodiments, a metal mesoporphyrin compound may be formed by hemin transmetallation and subsequent hydrogenation of the tin protoporphyrin IX to form a metal mesoporphyrin. In other embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a protoporphyrin methyl ester from hemin and converting the protoporphyrin methyl ester intermediate to a metal mesoporphyrin compound through metal insertion and hydrogenation. In other embodiments, a metal mesoporphyrin compound may be formed from hemin by a hydrogen-free hydrogenation method to form a mesoporphyrin IX intermediate followed by metal insertion and hydrogenation. In embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a mesoporphyrin IX dihydrochloride intermediate compound and converting the mesoporphyrin IX intermediate to a metal mesoporphyrin compound through metal insertion.Type: GrantFiled: April 15, 2014Date of Patent: November 10, 2015Assignee: INFACARE PHARMACEUTICAL CORPORATIONInventors: Christopher P. Boucher, David Roe
-
Patent number: 9107927Abstract: Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.Type: GrantFiled: August 14, 2014Date of Patent: August 18, 2015Assignee: Infacare Pharmaceutical CorporationInventors: George S. Drummond, Robert Caroselli, Keith A. Cooke, Daniel Levin, David G. Roe, Christopher P. Boucher
-
Patent number: 8835416Abstract: Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.Type: GrantFiled: September 5, 2013Date of Patent: September 16, 2014Assignee: Infacare Pharmaceutical CorporationInventors: George S. Drummond, Robert Caroselli, Keith A. Cooke, Daniel Levin, David G. Roe, Christopher P. Boucher
-
Publication number: 20140228560Abstract: Embodiments describe methods of synthesizing metal mesoporphyrin compounds. In embodiments, a metal mesoporphyrin compound may be formed by hemin transmetallation and subsequent hydrogenation of the tin protoporphyrin IX to form a metal mesoporphyrin. In other embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a protoporphyrin methyl ester from hemin and converting the protoporphyrin methyl ester intermediate to a metal mesoporphyrin compound through metal insertion and hydrogenation. In other embodiments, a metal mesoporphyrin compound may be formed from hemin by a hydrogen-free hydrogenation method to form a mesoporphyrin IX intermediate followed by metal insertion and hydrogenation. In embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a mesoporphyrin IX dihydrochloride intermediate compound and converting the mesoporphyrin IX intermediate to a metal mesoporphyrin compound through metal insertion.Type: ApplicationFiled: April 15, 2014Publication date: August 14, 2014Applicant: INFACARE PHARMACEUTICAL CORPORATIONInventors: Christopher P. BOUCHER, David ROE
-
Patent number: 8735574Abstract: Embodiments describe methods of synthesizing metal mesoporphyrin compounds. In embodiments, a metal mesoporphyrin compound may be formed by hemin transmetallation and subsequent hydrogenation of the tin protoporphyrin IX to form a metal mesoporphyrin. In other embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a protoporphyrin methyl ester from hemin and converting the protoporphyrin methyl ester intermediate to a metal mesoporphyrin compound through metal insertion and hydrogenation. In other embodiments, a metal mesoporphyrin compound may be formed from hemin by a hydrogen-free hydrogenation method to form a mesoporphyrin IX intermediate followed by metal insertion and hydrogenation. In embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a mesoporphyrin IX dihydrochloride intermediate compound and converting the mesoporphyrin IX intermediate to a metal mesoporphyrin compound through metal insertion.Type: GrantFiled: March 30, 2012Date of Patent: May 27, 2014Assignee: Infacare Pharmaceutical CorporationInventors: Christopher P. Boucher, David Roe
-
Publication number: 20140005380Abstract: Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.Type: ApplicationFiled: September 5, 2013Publication date: January 2, 2014Applicant: INFACARE PHARMACEUTICAL CORPORATIONInventors: George S. DRUMMOND, Robert CAROSELLI, Keith A. COOKE, Daniel LEVIN, David G. ROE, Christopher P. BOUCHER
-
Patent number: 8530458Abstract: Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.Type: GrantFiled: December 15, 2010Date of Patent: September 10, 2013Assignee: Infacare Pharmaceutical CorporationInventors: George S. Drummond, Robert Caroselli, Keith A. Cooke, Daniel Levin, David G. Roe, Christopher P. Boucher
-
Publication number: 20130158362Abstract: Some embodiments relate to methods of treating hyperbilirubinemia comprising administrating a therapeutic amount of a metalloporphyrin to an infant. Administration may occur when the infant's measured total serum bilirubin levels are at or below about the level suggested by the AAP nomogram for initiating phototherapy, when the infant's measured total serum bilirubin levels are at about the level suggested for initiating phototherapy in an infant, or when the infant's measured total serum bilirubin levels are at about the level suggested for initiating phototherapy. Administration may occur without regard to the total serum bilirubin level of the infant. In some embodiments, administration of the metalloporphyrin does not cause QT prolongation.Type: ApplicationFiled: November 30, 2012Publication date: June 20, 2013Applicant: INFACARE PHARMACEUTICAL CORPORATIONInventor: INFACARE PHARMACEUTICAL CORPORATION
-
Patent number: 8178664Abstract: A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.Type: GrantFiled: July 9, 2010Date of Patent: May 15, 2012Assignee: Infacare Pharmaceutical CorporationInventors: Robert Vukovich, Benjamin Levinson, George S. Drummond, Robert Caroselli, Kazimierz G. Antczak, Christopher Boucher, Richard Mortimer, Danny Levin, Keith A. Cooke
-
Patent number: 7960371Abstract: Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.Type: GrantFiled: October 4, 2007Date of Patent: June 14, 2011Assignee: Infacare Pharmaceutical CorporationInventors: George S. Drummond, Robert Caroselli, Keith A. Cooke, Daniel Levin, David G. Roe, Christopher P. Boucher
-
Patent number: 7777028Abstract: A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.Type: GrantFiled: December 14, 2007Date of Patent: August 17, 2010Assignee: Infacare Pharmaceutical CorporationInventors: Robert A. Vukovich, Benjamin Levinson, George S. Drummond, Robert Caroselli, Kazimierz G. Antczak, Christopher P. Boucher, Richard Mortimer, Daniel Levin, Keith A. Cooke
-
Patent number: 7375216Abstract: A method of preparing metal mesoporphyrin compounds is described. A metal mesoporphyrin compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to a metal mesoporphyrin compound through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.Type: GrantFiled: March 29, 2004Date of Patent: May 20, 2008Assignee: InfaCare Pharmaceutical CorporationInventors: Robert Vukovich, Benjamin Levinson, George S. Drummond, Robert Caroselli, Kazimierz G. Antczak, Christopher Boucher, Richard Mortimer, Danny Levin, Keith A. Cooke