Patents Assigned to Infinity Discovery, Inc.
  • Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
    Patent number: 8609706
    Abstract: The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
    Type: Grant
    Filed: May 15, 2012
    Date of Patent: December 17, 2013
    Assignee: Infinity Discovery, Inc.
    Inventors: Alfredo C. Castro, Kristopher M. Depew, Michael J. Grogan, Charles W. Johannes, Edward B. Holson, Brian T. Hopkins, Gregg F. Keaney, Nii O. Koney, Tao Liu, David A. Mann, Marta Nevalainen, Stephane Peluso, Lawrence Blas Perez, Daniel A. Snyder, Thomas T. Tibbitts
  • Analogs of Benzoquinone-Containing Ansamycins and Methods of Use Thereof
    Publication number: 20130203724
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Application
    Filed: August 20, 2012
    Publication date: August 8, 2013
    Applicant: Infinity Discovery, Inc.
    Inventors: Julian Adams, Yun Gao, Asimina T. Georges Evangelinos, Louis Grenier, Roger H. Pak, James R. Porter, James L. Wright
  • Cyclopamine lactam analogs and methods of use thereof
    Patent number: 8431566
    Abstract: The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: April 30, 2013
    Assignee: Infinity Discovery, Inc.
    Inventors: Alfredo Castro, Michael J. Grogan, Andre Lescarbeau, Martin Tremblay
  • Heterocyclic cyclopamine analogs and methods of use thereof
    Patent number: 8426436
    Abstract: The present invention relates to steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: April 23, 2013
    Assignee: Infinity Discovery, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Martin Tremblay
  • Ansamycin formulations and methods of use thereof
    Patent number: 8357676
    Abstract: Provided herein, inter alia, are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 (“Hsp90”).
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: January 22, 2013
    Assignee: Infinity Discovery, Inc.
    Inventors: Brian C. Austad, Louis Grenier, Edward B. Holson, John J. Lee, Roger H. Pak, James R. Porter, James L. Wright
  • Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
    Patent number: 8304428
    Abstract: The present invention relates to heterocyclic compounds that bind to Bcl proteins and inhibit Bcl function, compositions comprising such compounds, and methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: November 6, 2012
    Assignee: Infinity Discovery, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Edward B. Holson, Brian T. Hopkins, Nii O. Koney, Stephane Peluso, Daniel A. Snyder
  • Cyclopamine lactam analogs and methods of use thereof
    Patent number: 8293760
    Abstract: The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: October 23, 2012
    Assignee: Infinity Discovery, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Andre Lescarbeau, Martin R. Tremblay
  • Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners
    Publication number: 20110213145
    Abstract: The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
    Type: Application
    Filed: April 19, 2011
    Publication date: September 1, 2011
    Applicant: Infinity Discovery, Inc.
    Inventors: Alfredo C. Castro, Kristopher M. Depew, Michael J. Grogan, Charles W. Johannes, Edward B. Holson, Brian T. Hopkins, Gregg F. Keaney, Nii O. Koney, Tao Liu, David A. Mann, Marta Nevalainen, Stephane Peluso, Lawrence B. Perez, Daniel A. Snyder, Thomas T. Tibbitts
  • Heterocyclic cyclopamine analogs and methods of use thereof
    Patent number: 7994191
    Abstract: The present invention relates to steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: August 9, 2011
    Assignee: Infinity Discovery, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Martin Tremblay
  • Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners
    Publication number: 20110160259
    Abstract: One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
    Type: Application
    Filed: November 30, 2010
    Publication date: June 30, 2011
    Applicant: Infinity Discovery, Inc.
    Inventors: Alfredo C. Castro, Edward B. Holson, Brian T. Hopkins, Nii O. Koney, Daniel A. Snyder, Thomas T. Tibbitts
  • Cyclopamine lactam analogs and methods of use thereof
    Patent number: 7964590
    Abstract: The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: June 21, 2011
    Assignee: Infinity Discovery, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Andre Lescarbeau, Martin Tremblay
  • Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
    Patent number: 7928244
    Abstract: The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: April 19, 2011
    Assignee: Infinity Discovery, Inc.
    Inventors: Alfredo C. Castro, Kristopher M. Depew, Michael J. Grogan, Charles W. Johannes, Edward B. Holson, Brian T. Hopkins, Gregg F. Keaney, Nii O. Koney, Tao Liu, David A. Mann, Marta Nevalainen, Stephane Peluso, Lawrence B. Perez, Daniel A. Snyder, Thomas T. Tibbitts
  • Analogs of Benzoquinone-Containing Ansamycins and Methods of Use Thereof
    Publication number: 20110086110
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Application
    Filed: October 6, 2010
    Publication date: April 14, 2011
    Applicant: Infinity Discovery, Inc.
    Inventors: Julian Adams, Yun Gao, Asimina T. Georges Evangelinos, Louis Grenier, Roger H. Pak, James R. Porter, James L. Wright
  • Cyclopamine analogues and methods of use thereof
    Patent number: 7875628
    Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: January 25, 2011
    Assignee: Infinity Discovery, Inc.
    Inventors: Julian Adams, Alfredo C. Castro, Michael A. Foley, Somarajannair Janardanannair, Marta Nevalainen, James R. Porter, Martin R. Tremblay
  • Methods for Analysis of Hedgehog Pathway Inhibitors
    Publication number: 20100099116
    Abstract: One aspect of the present invention relates to a method of ascertaining the inhibitory activity in a mammal of a candidate inhibitor of the hedgehog pathway. In certain embodiments, the candidate inhibitor is administered systemically. In certain embodiments, the mammal is a rodent or primate. In certain embodiments, the mammal is a mouse. In certain embodiments, the candidate inhibitor is a small molecule or natural product.
    Type: Application
    Filed: January 14, 2008
    Publication date: April 22, 2010
    Applicant: Infinity Discovery, Inc.
    Inventors: Kerrie L. Faia, Everton Mandley, Wei Niu, Christine Pien
  • Heterocyclic cyclopamine analogs and methods of use thereof
    Patent number: 7648994
    Abstract: The present invention relates to steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: January 19, 2010
    Assignee: Infinity Discovery, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Martin Tremblay
  • INHIBITORS OF FATTY ACID AMIDE HYDROLASE
    Publication number: 20090099131
    Abstract: The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). The present invention also provides methods for treating an FAAH mediated disease, disorder or condition by administering a therapeutically effective amount of a provided compound of the formulae (I), (II) or (III), or a pharmaceutical composition thereof, to a patient in need thereof. Additionally, the present invention provides methods for inhibiting FAAH in a patient by administering a therapeutically effective amount of a compound of the formulae (I), (II) or (III), or a pharmaceutical composition thereof, to a patient in need thereof.
    Type: Application
    Filed: October 10, 2007
    Publication date: April 16, 2009
    Applicant: Infinity Discovery, Inc.
    Inventors: Julian Adams, Mark L. Behnke, Alfredo C. Castro, Catherine A. Evans, Louis Grenier, Michael J. Grogan, Tao Liu, Daniel A. Snyder, Thomas T. Tibbitts
  • HETEROCYCLIC CYCLOPAMINE ANALOGS AND METHODS OF USE THEREOF
    Publication number: 20080293755
    Abstract: The present invention relates to steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer.
    Type: Application
    Filed: March 7, 2008
    Publication date: November 27, 2008
    Applicant: Infinity Discovery, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Martin Tremblay
  • CYCLOPAMINE LACTAM ANALOGS AND METHODS OF USE THEREOF
    Publication number: 20080287420
    Abstract: The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer.
    Type: Application
    Filed: March 7, 2008
    Publication date: November 20, 2008
    Applicant: Infinity Discovery, Inc.
    Inventors: Alfredo Castro, Michael J. Grogan, Andre Lescarbeau, Martin Tremblay
  • Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners
    Publication number: 20080114167
    Abstract: The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
    Type: Application
    Filed: August 21, 2007
    Publication date: May 15, 2008
    Applicant: Infinity Discovery, Inc.
    Inventors: Alfredo CASTRO, Kristopher DEPEW, Michael GROGAN, Charles JOHANNES, Edward HOLSON, Brian HOPKINS, Gregg KEANEY, Nii KONEY, Tao LIU, David MANN, Marta NEVALAINEN, Stephane PELUSO, Lawrence PEREZ, Daniel SNYDER, Thomas TIBBITTS