Abstract: The invention includes a phenylephrine product including an aqueous phenylephrine solution, a tonicity adjusting agent, at least one pH adjusting agent, at least one buffering agent and water for injection, wherein the phenylephrine solution is does not comprise sodium metabisulfite, wherein the phenylephrine product is sterile and ready-to-use and contain an oxygen absorber to keep the oxygen dissolved below 1 ppm. The invention includes methods of making and using the phenylephrine product.
Abstract: The invention relates to a sterile, ready-to-use, stable aqueous solution of ketamine suitable for direct intravenous infusion to a patient in need thereof, wherein the composition is disposed within a sealed infusion container as a premixture. The invention further relates to aqueous solutions of ketamine that are free of antimicrobials such as benzethonium chloride and are shelf-stable. The pharmaceutical compositions can be used, for example, wherein the subject is in need of anesthesia for a diagnostic or a surgical procedure.
Abstract: Terminally sterilized, preservative-free aqueous midazolam solution comprising 0.25 to 1.5 mg/ml of midazolam, a tonicity adjusting agent to provide an osmolality of from 260 and 320 mosm/kg and sufficient acid and optionally a base to provide a pH of from about 2.5 to 3.5 with the remainder water for injection packaged in a flexible plastic container.
Abstract: A sterile, sulfite-free aqueous norepinephrine solution comprising up to about 0.2 mg/ml of norepinephrine concentration (as free base), a tonicity adjusting agent, at a pH where the norepinephrine is soluble which is packaged in a flexible plastic container, characterized by being storage stable for from about 12 months to about 24 months at room temperature of about 25° C.
Abstract: A sterile, sulfite-free aqueous norepinephrine solution comprising up to about 0.2 mg/ml of norepinephrine concentration (as free base), a tonicity adjusting agent, at a pH where the norepinephrine is soluble which is packaged in a flexible plastic container, characterized by being storage stable for from about 12 months to about 24 months at room temperature of about 25° C.
Abstract: Terminally sterilized, preservative-free aqueous midazolam solution comprising 0.25 to 1.5 mg/ml of midazolam, a tonicity adjusting agent to provide an osmolality of from 260 and 320 mosm/kg and sufficient acid and optionally a base to provide a pH of from about 2.5 to 3.5 with the remainder water for injection packaged in a flexible plastic container.