Abstract: A one-time use plastic disposable lockbox enclosing an infusion system including the infusion device, method of delivery such as tubing, and source reservoir such as a fluid bag or syringe is provided. The lockbox includes first and second thermoplastic shells joinable along a separation plane to define a housing. The housing carries an IV bag volume abutting a periphery of a filled standard IV bag to restrain movement of that IV bag along the separation plane and a pump volume abutting a periphery of an IV pump to restrain movement of that IV pump along the separation plane. A channel extends between the pump volume and an exterior of the housing to allow egress of a standard IV line from the housing.