Patents Assigned to InGeneron, Inc.
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Patent number: 11369716Abstract: Methods are described for generating autologous tissue grafts, including generating grafts at the point of care, which include isolated cell populations that are enriched with stem cells and are mixed with biological fillers including hyaluronic acid and derivatives thereof. The hyaluronic acid localizes the cells to a desired injection site and stimulates collagen production thus enhancing the viability and the longevity of the graft.Type: GrantFiled: February 21, 2019Date of Patent: June 28, 2022Assignees: INGENERON, INC., Board of Regents, The University of Texas SystemInventors: Andrew M Altman, Eckhard U. Alt, Michael E. Coleman
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Patent number: 10905722Abstract: Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.Type: GrantFiled: March 7, 2018Date of Patent: February 2, 2021Assignees: INGENERON INC., ALLIANCE OF CARDIOVASCULAR RESEARCHERSInventors: Eckhard Alt, Tahereh Karimi
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Patent number: 10760059Abstract: Methods of differentiating unmodified adult stem cells into functional beta-like cells are provided, as well as compositions, tissues and devices containing such cells. The method requires inducing sequential expression of PDX1, NGN3, and MAFA in these stem cells to form reprogrammed beta cells. Methods of treating diabetes are also provided, comprising obtaining stem cells, preferably from a patient with diabetes, inducing sequential expression of PDX1, NGN3, and MAFA, in said stem cells to form reprogrammed beta cells, and introducing said reprogrammed beta cells into a pancreas of said patient. Alternatively, it may be possible to inject such cells systemically, if the cells are targeted for the pancreas. In yet another embodiment, the reprogrammed beta cells are placed into an artificial pancreas that is surgically placed or injected into the patient.Type: GrantFiled: May 9, 2017Date of Patent: September 1, 2020Assignee: InGeneron Inc.Inventors: Eckhard U. Alt, Tahereh Karimi
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Publication number: 20190175787Abstract: Methods are described for generating autologous tissue grafts, including generating grafts at the point of care, which include isolated cell populations that are enriched with stem cells and are mixed with biological fillers including hyaluronic acid and derivatives thereof. The hyaluronic acid localizes the cells to a desired injection site and stimulates collagen production thus enhancing the viability and the longevity of the graft.Type: ApplicationFiled: February 21, 2019Publication date: June 13, 2019Applicants: Board of Regents, The University of Texas System, Ingeneron, Inc.Inventors: Andrew M. Altman, Eckhard U. Alt, Michael E. Coleman
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Patent number: 10238770Abstract: Methods are described for generating autologous tissue grafts, including generating grafts at the point of care, which include isolated cell populations that are enriched with stem cells and are mixed with biological fillers including hyaluronic acid and derivatives thereof. The hyaluronic acid localizes the cells to a desired injection site and stimulates collagen production thus enhancing the viability and the longevity of the graft.Type: GrantFiled: November 2, 2015Date of Patent: March 26, 2019Assignees: Ingeneron, Inc., Board of Regents, The university of Texas SystemInventors: Andrew M Altman, Eckhard U. Alt, Michael E. Coleman
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Patent number: 9913865Abstract: Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.Type: GrantFiled: December 28, 2015Date of Patent: March 13, 2018Assignees: InGeneron Inc., Alliance of Cardiovascular ResearchInventors: Eckhard Alt, Tahereh Karimi
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Publication number: 20170224736Abstract: Methods for the extraction and processing of umbilical stem cells for therapeutic and diagnostic purposes are disclosed. The methods provide high regenerative cell numbers and high cell viability. Further, the methods do not require culturing the cells in serum or growth factors. Certain aspects of the present invention concern methods of processing tissue for use in regenerative medicine. In another aspect of the invention, the tissue is processed and the resulting cell preparation administered within one and the same medical procedure.Type: ApplicationFiled: July 31, 2015Publication date: August 10, 2017Applicant: Ingeneron, Inc.Inventors: Eckhard U Alt, Ivonne Guzman Bruno, Timo Nazari Shafti, Michael E Coleman, Anita Kadala
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Patent number: 9663762Abstract: Methods for recovering target cells using degradable three dimensional matrices are described.Type: GrantFiled: May 16, 2013Date of Patent: May 30, 2017Assignee: Ingeneron, Inc.Inventors: Michael Coleman, Jody Vykoukal
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Publication number: 20170088623Abstract: This document provides prophylactic methods for reducing cancer metastasis by targeting LCN2, MMP9, and CX-CR4.Type: ApplicationFiled: September 30, 2015Publication date: March 30, 2017Applicants: Ingeneron, Inc., Board of Regents, The University of Texas SystemInventors: Eckhard U. Alt, Ralph B. Arlinghaus, Michael E. Coleman
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Publication number: 20160158292Abstract: Methods for the extraction and processing of umbilical stem cells for therapeutic and diagnostic purposes are disclosed. The methods provide high regenerative cell numbers and high cell viability. Further, the methods do not require culturing the cells in serum or growth factors.Type: ApplicationFiled: July 31, 2015Publication date: June 9, 2016Applicant: Ingeneron, Inc.Inventors: Eckhard Alt, Ivonne Guzman Bruno, Timo Nazari Shafti, Michael E Coleman, Anita Kadala
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Publication number: 20160051729Abstract: Methods are described for generating autologous tissue grafts, including generating grafts at the point of care, which include isolated cell populations that are enriched with stem cells and are mixed with biological fillers including hyaluronic acid and derivatives thereof. The hyaluronic acid localizes the cells to a desired injection site and stimulates collagen production thus enhancing the viability and the longevity of the graft.Type: ApplicationFiled: November 2, 2015Publication date: February 25, 2016Applicants: Ingeneron, Inc., Board of Regents, The University of Texas SystemInventors: Andrew M Altman, Eckhard U. Alt, Michael E. Coleman
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Patent number: 9173975Abstract: Methods are described for generating autologous tissue grafts, including generating grafts at the point of care, which include isolated cell populations that are enriched with stem cells and are mixed with hyaluronic acid and derivatives thereof. The hyaluronic acid localizes the cells to a desired injection site and stimulates collagen production thus enhancing the viability and the longevity of the graft.Type: GrantFiled: April 23, 2010Date of Patent: November 3, 2015Assignees: Ingeneron, Inc., Board of Regents, The University of Texas SystemInventors: Andrew M. Altman, Eckhard U. Alt, Michael E. Coleman
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Publication number: 20150093809Abstract: This document describes methods and an apparatus for recovery of a cell-enriched matrix and cells (e.g., regenerative cells) from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.Type: ApplicationFiled: September 27, 2013Publication date: April 2, 2015Applicant: InGeneron, Inc.Inventors: Eckhard U. Alt, Ron Stubbers, Michael E. Coleman
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Publication number: 20150037387Abstract: Apparatus and methods are described for generating autologous tissue grafts, the apparatus including a point of care SVF isolation unit that includes a tissue digestion chamber in fluid communication with a lipid separating chamber, whereby SVF cells are isolated without centrifugation; and a cell seeding chamber in fluid communication with the SVF isolation unit, said cell seeding chamber adapted to support a cell scaffold. Methods and materials for cell seeding, including through the provision of micro rough scaffold surfaces, are also provided.Type: ApplicationFiled: October 20, 2014Publication date: February 5, 2015Applicants: Board of Regents of the University of Texas System, Ingeneron, Inc.Inventors: Michael E. Coleman, Eckhard U. Alt, Ron Stubbers
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Patent number: 8865199Abstract: Apparatus and methods are described for generating autologous tissue grafts, the apparatus including a point of care SVF isolation unit that includes a tissue digestion chamber in fluid communication with a lipid separating chamber, whereby SVF cells are isolated without centrifugation; and a cell seeding chamber in fluid communication with the SVF isolation unit, said cell seeding chamber adapted to support a cell scaffold. Methods and materials for cell seeding, including through the provision of micro rough scaffold surfaces, are also provided.Type: GrantFiled: November 17, 2009Date of Patent: October 21, 2014Assignees: Ingeneron, Inc., Board of Regents of the University of Texas SystemInventors: Michael E. Coleman, Eckhard U. Alt, Ron Stubbers
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Publication number: 20130337551Abstract: A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form.Type: ApplicationFiled: October 26, 2012Publication date: December 19, 2013Applicant: InGeneron Inc.Inventors: Ron Stubbers, Michael Coleman
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Patent number: 8309342Abstract: A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form.Type: GrantFiled: December 3, 2008Date of Patent: November 13, 2012Assignee: InGeneron, Inc.Inventors: Ron Stubbers, Michael E. Coleman
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Publication number: 20120224053Abstract: Optical detection platforms are described as well as methods of using such platforms to perform quantitative assays.Type: ApplicationFiled: June 17, 2010Publication date: September 6, 2012Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, INGENERON, INC.Inventors: Jody Vykoukal, Daynene M. Vykoukal, Gregory P. Stone, Eckhard U. Alt
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Publication number: 20120219561Abstract: This document provides prophylactic methods for reducing cancer metastasis by targeting LCN2, MMP9, and CX-CR4.Type: ApplicationFiled: August 2, 2010Publication date: August 30, 2012Applicants: Ingeneron, Inc., Board of Regents, The University of Texas SystemInventors: Eckhard U. Alt, Ralph B. Arlinghaus, Michael E. Coleman
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Publication number: 20100310527Abstract: Methods and compositions are provided for lineage predetermination of cellular transplants including through liposome mediated transfection with aqueous protein extracts from populations of differentiated mammalian cells, or cellular fractions thereof, wherein the differentiated mammalian cells are enriched in one or more of adipocytes, chondrocytes, endothelial cells, hepatocytes, cardiomyocytes, smooth muscle cells, skeletal muscle cells, cardiac pacemaker cells, Schwann cells, pancreatic islet cells, hematopoietic cells, myeloblasts, neurons, and osteoblasts.Type: ApplicationFiled: January 8, 2010Publication date: December 9, 2010Applicants: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, INGENERON, INC.Inventors: Eckhard U. Alt, Kirstin Schimrosczyk, Michael E. Coleman