Patents Assigned to Ingeneus, Inc.
  • Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes
    Patent number: 7309569
    Abstract: A complex includes: (1) a probe containing a heteropolymeric probe sequence of nucleic acids or nucleic acid analogues; and (2) a target containing a heteropolymeric target sequence of nucleic acids or nucleic acid analogues, wherein: (a) at least one of the probe and the target is purified or synthetic; and (b) the heteropolymeric probe sequence is bonded to the heteropolymeric target sequence by Watson-Crick complementary base interaction or by homologous base interaction, provided that when the complex is a duplex and the heteropolymeric probe sequence is antiparallel to the heteropolymeric target sequence, the heteropolymeric probe sequence is bonded to the heteropolymeric target sequence by homologous base interaction, and provided that when the complex is a triplex, the complex is free of recombination proteins. A method for assaying a target includes detecting formation of the complex.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: December 18, 2007
    Assignee: Ingeneus, Inc.
    Inventors: Glen H. Erikson, Jasmine I. Daksis, Ivana Kandic, Pierre Picard
  • Homogeneous assay of biopolymer binding by means of multiple measurements under varied conditions
    Patent number: 7220541
    Abstract: A method for homogeneously assaying biopolymer bonding includes obtaining signals from a test sample before, during and/or after the application of stimulus to the test sample and correlating the signals. The signals, whose magnitude correlate with binding affinity, can be, for example, electrical conductance and/or fluorescent intensity. The stimulus can be, for example, electric voltage and/or laser radiation. Preferably, different types of signals are measured and compared so as to enhance the reliability of the assay.
    Type: Grant
    Filed: July 23, 2001
    Date of Patent: May 22, 2007
    Assignee: Ingeneus, Inc.
    Inventors: Glen H. Erikson, Jasmine I. Daksis, Pierre Picard
  • Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism
    Patent number: 7052844
    Abstract: A purification method includes bonding a probe to a target in a sample to form a complex, and separating the sample from the complex to separate in a sequence specific manner the target from the sample. The complex, which is immobilized on a support, is a duplex, triplex or quadruplex formed by Watson-Crick complementary base interaction or by homologous base interaction, provided that when the complex is a duplex and the heteropolymeric probe sequence is antiparallel to the heteropolymeric target sequence, the heteropolymeric probe sequence is bonded to the heteropolymeric target sequence by homologous base interaction, and provided that when the complex is a triplex, the complex is free of recombination proteins. A kit for performing the method includes the support and the probe.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: May 30, 2006
    Assignee: Ingeneus, Inc.
    Inventors: Ian J. Atkinson, Glen H. Erikson, Jasmine I. Daksis, Pierre Picard