Abstract: The present disclosure refers to a fusion protein having an antibody against Tie-2 or antigen-binding fragment thereof and a vascular endothelial growth factor (VEGF)-binding domain, methods for making the fusion protein, and pharmaceutical compositions and methods for preventing or treating angiogenic or vascular diseases or regulating angiogenesis, endothelial signaling, inflammation, and/or vascular leakage, which comprise the fusion protein.
Type:
Application
Filed:
January 12, 2023
Publication date:
September 14, 2023
Applicant:
INGENIA Therapeutics Inc.
Inventors:
Minkyung Choo, Kwangsoo Kim, Sangyeul Han, Philip Durost