Abstract: Provided herein arm binding polypeptides that specifically bind 5T4. More specifically, provided herein are fusion proteins, including multivalent and/or multispecific constructs and chimeric antigen receptors, that bind 5T4. Also provided are pharmaceutical compositions containing the polypeptides, nucleic acid molecules encoding the polypeptides and vectors and cells thereof, and methods of use and uses of the provided 5T4 binding polypeptides for treating diseases and conditions, such as cancer.
Type:
Application
Filed:
October 9, 2019
Publication date:
November 4, 2021
Applicant:
Inhlbrx, inc.
Inventors:
John C. TIMMER, Michael D. KAPLAN, Katelyn M. WILLIS, Raiay A. PANDIT, Angelica N. SANABRIA, Sydney A. BARNES, Margaret E. HAERR, Brendan P. ECKELMAN, Rutger H. JACKSON