Abstract: Modified Thomsen-Friedenreich disaccharide (TFD) immunogen, preparation procedure, compositions containing it, uses, and treatment methods. More specifically, the present invention refers to a immunogen obtained by modifying TFD, and comprising the general formula D-TFD-Lys(n)-C, wherein D is a hydrophobic terminal residue, TFD is disaccharide Gal?3GalNAc?; Lys(n) is a lysine connector, and n is an integer between 1 and 5, and C is a carrier. In a preferred embodiment, the modified invention immunogen comprises the general formula Bzl?TFD-Lys5-KLHs, wherein Bzl is benzyl, TFD is disaccharide Gal?3GalNAc?; Lys5 is penta-lysine, and KLHs is succinilated Keyhole limpets hemocyanin.