Patents Assigned to INISTITI IT GI ISTAV/E Dm ICCV
  • 5-hydroxytryptamine 1B receptor-stimulating agent for use as a promoter of satellite cells self-renewal and/or differentiation
    Patent number: 11344515
    Abstract: The present invention relates to the field of muscle regeneration, and more particularly to the replenishment of the in vivo muscle stem cells pool. It more specifically relates to a 5-hydroxytryptamine B1 receptor-stimulating agent, and to a composition comprising said agent, for use as i) a promoter of satellite cells self-renewal and/or differentiation, and/or ii) an agent preventing and/or inhibiting the satellite cells pool exhaustion. The invention further encompasses therapeutic and screening methods.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: May 31, 2022
    Assignees: INSTITUT PASTEUR, UNIVERSITE PARIS DESCARTES, CENTRE HOSPITALIER SAINTE ANNE PARIS, INISTITI IT GI ISTAV/E Dm ICCV
    Inventors: Fabrice Bruno Chretien, Raphael Gaillard, Pierre Rocheteau, Olivier Mir