Abstract: An injector for delivery of a pharmaceutical composition. The injector includes a cylinder extending along a longitudinal axis, the cylinder having an inner wall, an outer wall, and an outlet at an outlet end opposite an actuating end, a piston assembly comprising a compressible section between an actuating piston element and a passive piston element, which piston elements abut the inner wall of the cylinder at abutting interfaces thereby sealing the compressible section when the piston assembly is inserted in the cylinder, the compressible section comprising a compressible fluid and a resilient frame linking the actuating piston element to the passive piston element. The injector is suited for pre-filled injectors allowing long term storage of protein based pharmaceutical compositions.

Abstract: A piston for use in an injector comprising a cylinder having a longitudinal axis and an inner wall, which piston has a deformable sealing element with a convex surface, which deformable sealing element when the piston is inserted in the cylinder abuts the inner wall of the cylinder at an abutting interface and seals an annular gap between the piston and the inner wall of the cylinder. The abutting interface and the deformable sealing element have axial dimensions parallel with the longitudinal axis. The ratio between the axial dimension of the abutting interface and the axial dimension of the deformable sealing element is in the range between 0.01 and 0.2. In another aspect, an injector includes the piston and is used in a disposable syringe of the piston. The piston can prevent refilling of a syringe.

Abstract: The present invention relates to an injector for preventing accidental needle sticks comprising:—a cylinder extending along a longitudinal axis, an inner wall and an outer wall, the cylinder having an outlet at an outlet end opposite an actuating end and a finger grip on the outer wall, which finger grip is positioned between the outlet end and the actuating end,—a piston having a piston body and a deformable sealing element, which deformable sealing element abuts the inner wall of the cylinder at an abutting interface and seals an annular gap between the piston body and the inner wall of the cylinder when the piston is inserted in the cylinder,—a needle guard for mounting on the outside of the cylinder from the outlet end or the actuating end, which needle guard comprises a barrel with a mounting end opposite an operating end, the barrel having a slot for receiving the finger grip of the cylinder when the needle guard is mounted on the cylinder, which slot extends from the mounting end towards the operating

Abstract: A piston for use in an injector comprising a cylinder having a longitudinal axis and an inner wall, which piston has a deformable sealing element with a convex surface, which deformable sealing element when the piston is inserted in the cylinder abuts the inner wall of the cylinder at an abutting interface and seals an annular gap between the piston and the inner wall of the cylinder. The abutting interface and the deformable sealing element have axial dimensions parallel with the longitudinal axis. The ratio between the axial dimension of the abutting interface and the axial dimension of the deformable sealing element is in the range between 0.01 and 0.2. In another aspect, an injector includes the piston and is used in a disposable syringe of the piston. The piston can prevent refilling of a syringe.

Abstract: A piston for use in an injector comprising a cylinder having a longitudinal axis and an inner wall, which piston has a deformable sealing element with a convex surface, which deformable sealing element when the piston is inserted in the cylinder abuts the inner wall of the cylinder at an abutting interface and seals an annular gap between the piston and the inner wall of the cylinder. The abutting interface and the deformable sealing element have axial dimensions parallel with the longitudinal axis. The ratio between the axial dimension of the abutting interface and the axial dimension of the deformable sealing element is in the range between 0.01 and 0.2. In another aspect, an injector includes the piston and is used in a disposable syringe of the piston. The piston can prevent refilling of a syringe.

Abstract: A piston for use in an injector comprising a cylinder having a longitudinal axis and an inner wall, which piston has a deformable sealing element with a convex surface, which deformable sealing element when the piston is inserted in the cylinder abuts the inner wall of the cylinder at an abutting interface and seals an annular gap between the piston and the inner wall of the cylinder. The abutting interface and the deformable sealing element have axial dimensions parallel with the longitudinal axis. The ratio between the axial dimension of the abutting interface and the axial dimension of the deformable sealing element is in the range between 0.01 and 0.2. In another aspect, an injector includes the piston and is used in a disposable syringe of the piston. The piston can prevent refilling of a syringe.