Abstract: A means for decreasing bacterial virulence in a mammal including man or in a plant by inhibition of the Type III secretion system at concentrations that do not prevent or substantially reduce bacterial growth comprises an N-substituted 7-quinolylmethyl amine, in particular one that is further substituted in 5- and 8-position on the quinoline ring. A corresponding therapeutic method and a pharmaceutical composition are also disclosed.
Abstract: A method for identifying antibacterial agents comprises depleting bacteria of a strain comprising a luxAB construct of Ca2+, incubating the Ca2+ depleted bacteria with an agent the antibacterial effect of which shall be determined, recording the light emitted by the bacteria upon addition of an aldehyde, the incubation being carried out at a temperature which is at least 10° C. higher than the temperature at which the light is emitted by the bacteria. Also disclosed are corresponding probes and antibacterial agents identified by the method.
Type:
Grant
Filed:
September 4, 2003
Date of Patent:
April 1, 2008
Assignee:
Innate Pharmaceuticals AB
Inventors:
Anna Maria Kauppi, Jan Mikael Christian Elofsson, Hans Olof Wolf-Watz, Olov Roland Nordfelth, Markus Kristoffer Dahlgren
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