Abstract: Methods and compositions for treatment, diagnosis, and prevention of a virus comprise administering to a patient antibodies which react with regions of viral proteins and result in neutralization of infectivity and inactivation of functionally essential events in the life cycle of the virus. The antibodies recognize viral epitopes which fail to elicit an immune response in man when encountered through infection or naturally through the environment. In a preferred embodiment, the invention provides compositions and methods useful in the treatment and diagnosis of human immunodeficiency virus (HIV) infections. The present invention is also directed to chemical conjugates (herein referred to as MDP) adjuvant microparticle-antigen conjugates) that have a muramyl dipeptide backbone crosslinked into a microparticle capable of binding to the cell surface of Antigen Presenting Cells (APCs), to which is covalently attached one or more molecules having a reactive carbonyl group (i.e.
Abstract: The present invention relates to an immunostimulant and to the use of an immunostimulant in the form of a cross-linked muramyl dipeptide microparticle in the treatment of radiation exposure, radiation poisoning, and mitigating the toxic effects of radiotherapy.
Type:
Application
Filed:
September 30, 2009
Publication date:
September 29, 2011
Applicant:
INNATE THERAPEUTICS LIMITED
Inventors:
Frank B. Gelder, Gillian Alison Webster
Abstract: The present invention is concerned with novel immunostimulant microparticle compositions and their use as anti-infective agents in the treatment of bacterial and viral infections.
Type:
Application
Filed:
April 1, 2009
Publication date:
February 10, 2011
Applicant:
INNATE THERAPEUTICS LIMITED
Inventors:
Frank B. Gelder, Gillian Alison Webster