Abstract: An intra-calvarial implant (ICI) includes a housing including a sealed compartment having a top part, a bottom part and a side wall, and a current directing mechanism extending from the bottom part of the sealed compartment. The ICI also includes one or more electrodes for sensing electrical signals from the brain and/or for electrically stimulating one or more regions of the brain. The ICI includes at least one auxiliary electrode (that may be a reference and/or source/sink electrode) and an electronic circuitry module (ECM), sealingly disposed within the sealed compartment and operatively connected to the one or more electrodes and to the at least one reference electrode. The ECM controls the operation of the ICI and wirelessly communicates with an external telemetry device. The ICI includes a power harvesting device electrically connected to the ECM of the ICI for providing power thereto.

Abstract: Systems including intra-calvarial implants and/or subdermal implants are capable of stimulating cortical regions and sensing and electrical signals is implanted within or on a calvarial bone of a skull. The implants have current steering capability to change the current density profiles applied to selected cortical regions underlying the implant. The systems may track changes in the position and/or spatial parameters of a neural network by recording cortical electrical signals and processing them to compute the values of one or more network activity biomarkers. The systems may spatially track changes detected in network anatomical position and deliver the stimulation of the cortex to the network detected position by using current steering methods.

Abstract: An intra-calvarial implant (ICI) includes a housing including a sealed compartment having a top part, a bottom part and a side wall, and a current directing mechanism extending from the bottom part of the sealed compartment. The ICI also includes one or more electrodes for sensing electrical signals from the brain and/or for electrically stimulating one or more regions of the brain. The ICI includes at least one auxiliary electrode (that may be a reference and/or source/sink electrode) and an electronic circuitry module (ECM), sealingly disposed within the sealed compartment and operatively connected to the one or more electrodes and to the at least one reference electrode. The ECM controls the operation of the ICI and wirelessly communicates with an external telemetry device. The ICI includes a power harvesting device electrically connected to the ECM of the ICI for providing power thereto.

Abstract: Systems for treating a mood disorder in a patient includes implantable device(s) including one or more electrodes for sensing cortical signals and for stimulating one or more brain regions. Processor/controller(s) in communication with the electrode(s) receive and process cortical signals from electrode(s) and control the stimulating of brain region(s). The system includes portable communication device(s) operable by the patient and having software for acquiring ecological mood assessment (EMA) data representative of the patient's mood and communicating the EMA data to the processor/controller(s) and/or to at least one remote processor. Sensors may also be used to record patient data. The data is processed by the processor/controller(s), and/or by a processor of the portable communication device and/or by the remote processor(s) for modulating and/or controlling the stimulation the brain region(s) to treat the mood disorder. The implantable device(s) may include a power source.