Abstract: We found that Andrographolide binds to GSK-3?: In so doing, andrographolide changies the ontogeny of hippocampus and cortex amyloid plaques, and reducing tau phosphorylation around Amyloid-?. Andrographolide recovers spatial memory functions in an Alzheimer's model. Andrographolide and its derivatives may he used to heal patients with a damaged hippocampus and recover memory loss in such patients.
Type:
Application
Filed:
June 11, 2021
Publication date:
December 29, 2022
Applicant:
INNOBIOSCIENCE, LLC
Inventors:
Nibaldo C. INESTROSA, Juan L. HANCKE OROZCO
Abstract: Andrographolide 240 mg/day orally is the first treatment shown to significantly benefit progressive forms of Multiple Sclerosis in human patients.
Abstract: We found that Andrographolide binds to GSK-3?: In so doing, andrographolide prevents changes in neuropathology in an Alzheimer's model, reducing Amyloid-? peptide levels, changing the ontogeny of hippocampus and cortex amyloid plaques, and reducing tau phosphorylation around Amyloid-?. Andrographolide recovers spatial memory functions in an Alzheimer's model. Andrographolide and its derivatives may be used to treat Alzheimer's disease.
Type:
Application
Filed:
April 21, 2014
Publication date:
December 10, 2015
Applicant:
INNOBIOSCIENCE, LLC
Inventors:
Nibaldo C. INESTROSA, Juan L. HANCKE OROZCO
Abstract: The effectiveness of interferon for treating multiple sclerosis and other demyelinating diseases is synergistically potentiated by concomitant administration of a compound of Formula (I): wherein R1 is H, alkyl or OH, R2 is hydroxyalkyl or alkyl-O-L1, R3 is H or OH, X is C(?CH2), CH(OH), or spirooxirane-2, Z is CH2CH(OH) or C(=0), and R4 is an optionally substituted L2-alkyl or L2-alkenyl, wherein L2 is an optionally substituted 3-furanyl or 3-fur-3-enyl moiety.
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