Abstract: The present disclosure relates to dosage forms for extended release of an antibody or large protein. The extended release dosage forms comprise a biodegradable multi-block copolymer matrix and provide for extended release of antibody or large protein over a desired time period.
Type:
Application
Filed:
October 30, 2020
Publication date:
December 29, 2022
Applicant:
InnoCore Technologies Holding B.V.
Inventors:
Rob STEENDAM, Maria COIMBRA, Joana Catarina RIBEIRO ARAUJO, Johan ZUIDEMA, Tanja HENZLER, Alexandra KROG
Abstract: The invention is directed to a biodegradable, phase separated, thermoplastic multi-block copolymer, to a process for preparing a biodegradable, phase separated, thermoplastic multi-block copolymer, to the use of a biodegradable, semi-crystalline, phase separated, thermoplastic multi-block copolymer, and to a composition for the delivery of at least one biologically active compound to a host. The biodegradable, phase separated, thermoplastic multi-block copolymer of the invention comprises at least one amorphous hydrolysable pre-polymer (A) segment and at least one semi-crystalline hydrolysable pre-polymer (B) segment, wherein said multi-block copolymer under physiological conditions has a Tg of 37° C. or less and a Tm of 50-110° C.
Type:
Application
Filed:
September 30, 2020
Publication date:
October 20, 2022
Applicant:
InnoCore Technologies Holding B.V.
Inventors:
Henk HAITJEMA, Rob STEENDAM, Christine HIEMSTRA, Johan ZUIDEMA, Albert DOORNBOS, Thanh NGUYEN
Abstract: The present disclosure relates to extended release dosage forms of human chorionic gonadotropin (hCG) or derivatives or isoforms thereof. The extended release hCG dosage forms comprise biodegradable polymer microspheres and provide for extended release of hCG over a desired time period.
Type:
Application
Filed:
October 2, 2019
Publication date:
March 3, 2022
Applicants:
InnoCore Technologies Holding B.V., MHB Labs, Inc.
Inventors:
Johan ZUIDEMA, Rob STEENDAM, Joana Catarina Ribeiro ARAUJO, Ravi KACKER, Abraham MORGENTALER