Abstract: Disclosed is a novel piperidinedione compound of Formula 1 or a pharmaceutically acceptable salt thereof. Uses of the novel piperidinedione compound of Formula 1 or a pharmaceutically acceptable salt thereof as an anti-tumor agent or an immunomodulatory for treatment of CRBN protein-mediated diseases are disclosed. Also the compound or salt thereof can be used an E3 ligase binder in a PROTAC compound comprising a protein of interest ligand, a linker and an E3 ligase binder.
Type:
Application
Filed:
November 15, 2021
Publication date:
September 21, 2023
Applicant:
INNOCURE THERAPEUTICS, INC.
Inventors:
Hye-Dong YOO, Young-jun SHIN, Sung Jin KIM, Bo Kyoung KIM, Eun Myong LEE, So Hyun SHIN, Yong Hwan KIM, Seo Won CHOI, Min Sik BAE, Dongsik YANG, Jeong Hyun HONG, Jin Keon PAI