Abstract: Disclosed is system for executing service request. The system comprises a processing arrangement and data sources. The processing arrangement receives the service request and is configured to extract data from the data sources based on the service request. The data sources respond in response to a characteristic framework of the service request. The system further comprises an administrator module to permute the service request received by the processing arrangement in accordance with the characteristic framework employed by the data sources. The administrator module is configured to identify at least one attribute of the service request, obtain data corresponding to the at least one attribute of the service request from the data sources, normalize the obtained data and provide the normalized data to execute the service request, via the processing arrangement.

Abstract: Disclosed is a system for managing access to a plurality of remote digital platforms, wherein the system comprising a plurality of platform databases, wherein a given platform database is associated with a given remote digital platform and stores metadata related thereto, the system further comprising: a user device, wherein an existing user generates a user-request, and provides a remote digital platform identifier; an access-control database comprising information relating to roles and permissions associated with a plurality of users; a key-store database comprising private key associated with the plurality of users; and a server arrangement, the server arrangement: identifies a given remote digital platform server; obtains credentials from the existing user and verifies the credentials; determines roles and permissions associated with the existing user; retrieves a private key; verifies the private key with a public key stored at the given remote digital platform server; and enables a data communication ne

Abstract: A system and method for identifying potential targets for a pharmaceutical compound. The system includes a database arrangement operable to store existing data sources and information related to the pharmaceutical compound; and a processing module communicably coupled to database arrangement. The processing module is operable to receive information related to the pharmaceutical compound, wherein the information includes at least one known target associated with the pharmaceutical compound; extract plurality of targets from existing data sources, wherein the existing data sources comprise plurality of data records and wherein each of the plurality of targets is associated with the pharmaceutical compound in at least one data record; analyse druggability of each of plurality of targets to determine a preliminary set of targets; determine net score for each of the targets in preliminary set of targets; and designate targets with a net score above a predefined threshold, as potential targets.

Abstract: Disclosed is a system for executing access transactions of documents, for example, pertaining to drug discovery. A document and its metainformation are obtained, and value features are extracted from the document based on identification of concepts associated with the document. An importance score of the document is determined based on the value features and the metainformation. A summarized view of the document is constructed based on the value features, the metainformation, the concepts and the importance score. A unique identifier is generated for the document and associated with the summarized view and the concepts of the document. A search query is processed, and the summarized view of the document is retrieved and displayed based on the query. A request for accessing the document is validated, and document access is allowed when the request is validated successfully. The document access transaction may, for example, be facilitated using a blockchain platform.

Abstract: Disclosed is a system for gaining mechanistic insights into action of a drug using in-silico techniques. The system is communicably coupled to a phenotype ontological databank; wherein the system comprises a processor communicably coupled to a memory. The processor is configured to receive a first input of the drug, receive a second input relating to at least one phenotype associated with the drug, identify targets of the drug to obtain a drug target list, determine phenotypic targets of the drug, compare the drug target list with the phenotypic targets of the drug to identify a plurality of overlapping targets therebetween, generate a Drug-Target-Phenotype (DTP) network using the plurality of overlapping targets, compute relevant pathways by performing Signaling Pathway Impact Analysis (SPIA) for the plurality of overlapping targets, generate a Pathway-Target-Phenotype (PTP) network, and compute mechanistic insights into the action of the drug from the analysis of PTP network.

Abstract: A system and method for optimizing trial design for clinical trials. The system includes a computer system and a processor communicably coupled to a memory. The processor processes and structures raw trial data to a format suitable for input to train a machine learning model. The processor further identifies plurality of independent features of the raw trial data and screens actionable features. Further, the processor computes cut off range values for each of the actionable features and form a plurality of sub-groups of patients. The processor simulates patient response of each of the plurality of sub-groups of patients and identifies a sub-group of patients based upon population percentage and delta response that shows optimal clinical trial results in the simulated patient response.

Abstract: A system, that when operated, creates an index for a database arrangement, wherein the system includes a support server and an indexing server communicably coupled to the database arrangement, wherein the support server: receives a document, metadata pertaining to the document, and a document identifier associated with the document; extracts keywords from the document and store the keywords in a meta-document; stores the document identifier corresponding to the metadata in the database arrangement; and provides, to the indexing server, the meta-document and the document identifier; and wherein the indexing server: receives the meta-document and the document identifier from the support server; extracts keywords from the meta-document; and creates the index, wherein the index includes document identifier listed corresponding to the extracted keywords.

Abstract: A system for enabling in-silico phenotypic screening of drugs, the system is communicably coupled to a phenotype ontological databank. The system include a processor communicably coupled to a memory.

Abstract: A system for screening phenotypic targets associated with a disease using in-silico techniques. The system communicably coupled to a phenotype ontological databank including a plurality of phenotypes and phenotypic targets associated with each of the plurality of phenotypes; wherein the system includes a processor communicably coupled to a memory.

Abstract: A pharmaceutical composition comprising an effective amount of Dacomitinib as epidermal growth factor receptor (EGFR) inhibitor and a prostaglandin-Endoperoxide Synthase 2 (PTGS2) inhibitor, and one or more pharmaceutically acceptable excipients. A pharmaceutical composition comprising an effective amount of Dacomitinib as epidermal growth factor receptor (EGFR) inhibitor and an Adrenoceptor Beta 2 (ADRB2) inhibitor, and one or more pharmaceutically acceptable excipients. A method of treating pancreatic cancer, the method comprising the step of administering a therapeutically effective amount of the pharmaceutical composition to an individual in need thereof, the pharmaceutical composition comprising an effective amount of Dacomitinib as epidermal growth factor receptor (EGFR) inhibitor with a prostaglandin-Endoperoxide Synthase 2 (PTGS2) inhibitor or an Adrenoceptor Beta 2 (ADRB2) inhibitor, and one or more pharmaceutically acceptable excipients.

Abstract: A system and method for efficient management of a search database for retrieving context-based information, system including a database and processor, wherein the database includes columnar database for storing a plurality of documents, an ontological database configured to represent a plurality of concepts as nodes in a network and relationships between the concepts as edges between nodes and the search database configured to store an inverted index of the plurality of documents in the columnar database. Herein, the processor is configured to identify, using the ontological database, a set of concepts in each of the plurality of documents and store, in the search database, corresponding to a given document the set of concepts identified in the given document, and secondary concepts relating to the given document, wherein a secondary concept has a direct relationship in the network with at least one of the concepts in the set.

Abstract: A system for generating drug compositions for a disease target, the system comprises a database arrangement and a processor, wherein the processor is configured to receive information comprising one or more drugs associated with the disease target, identify a plurality of parameters associated with the disease target, using the database arrangement, construct a matrix to identify at least one of direct and indirect synergies of each of the drug with the plurality of parameters and assign weights thereby to each of the parameters with respect to each of the drug, based on the identified at least one of direct and indirect synergies, calculate a total score of each of the drug and rank the plurality of drugs based on the calculated total score and sort thereby the plurality of drugs. The processor then determines the one or more potential drug compositions on the basis of the sorted plurality of drugs.

Abstract: Disclosed herein is a system and method for enabling creating and managing structured tables on a blockchain thereby facilitating retrieval of data records with standard database operational commands and in a structured manner. Creating structured tables as per a defined schema provides for data storage in a manner which enables easy integration with existing business applications. Further, the system and method provides for storing unstructured data records in a structured manner in the blockchain.

Abstract: There is disclosed a system for providing information to a plurality of cancer patients, the system including a server arrangement communicably coupled to a database arrangement comprising a plurality of records and a user device, wherein the server arrangement is configured to create profile for a plurality of patients by receiving information from the user device, discover available treatment options for the created profile, list recruiting clinical trials for the created profile, list relevant oncologists for the created profile for at least one consultation and map the created profile against pre-existing profiles and connecting the determined profile and the pre-existing profiles for experience sharing purposes.

Abstract: A system and method for identifying at least one association of an entity. The system includes a processing module and a database arrangement communicably coupled to processing module. The processing module is operable to receive an input comprising data related to the entity; acquire web content related to the received input from a plurality of data sources; filter the acquired web content to obtain information relating to the entity; identify probable associations of the entity from the information relating to the entity using an ontology; determine for each of the probable associations, at least one of: a recency attribute, a frequency attribute, a proximity attribute, a semantics attribute; determine a probability score for each of the probable associations of the entity; and identify the at least one association of the entity from the probable associations, wherein the at least one association corresponds to a highest probability score.

Abstract: A system and a method for parsing a user query. The system includes a database arrangement operable to store an ontology; and a processing module communicably coupled to the database arrangement. The processing module operable to receive the user query; refine the user query to obtain a search query using an algorithm; generate a plurality of strings for the obtained search query; sort the plurality of strings in a decreasing order of length of the plurality of strings; assign a part-of-speech tag to each of the query segments of the plurality of strings based on the ontology; identify at least one of the query segments as at least one output class or at least one input class based on the assigned part-of-speech tags; and establish semantic associations between the query segments based on the ontology to obtain the parsed user query.

Abstract: A system for generating a novel molecular structure using a protein structure is disclosed. One or more processors generate a protein voxel representation of a protein structure that includes a multichannel three-dimensional (3D) grid that includes a plurality of channels. A cavity region is detected in the protein voxel representation based on a combination of rule-based detection and a deep learning based model. A cavity voxel representation of the cavity region is generated based on upscaling of a regional voxel of the detected cavity region. A ligand voxel representation of a ligand structure is generated based on the cavity voxel representation. A 3D voxel descriptor is determined for a protein-ligand complex based on the protein voxel representation and the ligand voxel representation. A simplified molecular-input line-entry system (SMILES) of a novel molecular structure is generated using a rich 3D embedding vector, which is based on the 3D voxel descriptor.

Abstract: Disclosed is a system for determining a temporal citation count for a document associated with an author, wherein the system comprises a database arrangement storing metadata related to the document, and a server arrangement communicably coupled to the database arrangement, wherein the server arrangement receives the metadata associated and employs dimensionality reduction techniques on the metadata to obtain a state data; designates the author of the document as a source node in the entity network comprising information related to a plurality of authors and citation history between the plurality of authors, wherein the remaining authors in the plurality of authors are designated as destination nodes determines an edge weight for edge between any of the source node and the destination nodes based on the state data; and aggregates the edge weight for the edges to obtain the temporal citation count.

Abstract: A system that provides recommendations of documents to a user, the system including a server arrangement, and a database arrangement that stores documents, wherein the server arrangement: receives identification details of the user, obtains prior work associated with the user, determines a user classification of the user based on: the identification details of the user, the prior work associated with the user, and an activity data of the user, determines a document classification for the documents based on a metainformation pertaining to the documents, determines a relevance factor for the documents with respect to the user based on the document classification of the documents, the user classification of the user, and activity data relating to the documents of a plurality of users with similar user classification as the user, and provides recommendations of documents to the user based on relevance factors of the documents.

Abstract: A system and method for efficient management of a search database for retrieving context-based information, system including a database and processor, wherein the database includes columnar database for storing a plurality of documents, an ontological database configured to represent a plurality of concepts as nodes in a network and relationships between the concepts as edges between nodes and the search database configured to store an inverted index of the plurality of documents in the columnar database. Herein, the processor is configured to identify, using the ontological database, a set of concepts in each of the plurality of documents and store, in the search database, corresponding to a given document the set of concepts identified in the given document, and secondary concepts relating to the given document, wherein a secondary concept has a direct relationship in the network with at least one of the concepts in the set.