Patents Assigned to InnoTERE GmbH
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Patent number: 9849211Abstract: The invention relates to dimensionally stable molded bone replacement elements made of mineral bone cement with residual hydraulic activity that contain at least one share of hardened mineral bone cement and at least one share of unconverted or unhardened reactive mineral bone cement, wherein the share of hardened mineral bone cement is 5% to 90% by weight. The dimensionally stable molded bone replacement elements have at least 5% of the maximum value of the strength of a completely hardened bone cement comprised of the same mineral components and with the same structural characteristics and reach compressive strengths in the range of 2 to 200 MPa. They are substantially free of water and can be converted under biological conditions.Type: GrantFiled: October 23, 2014Date of Patent: December 26, 2017Assignee: Innotere GmbHInventor: Berthold Nies
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Publication number: 20170340770Abstract: The invention relates to implant materials that are based on hydraulic cements in the form of one or more pastes, suspensions or dispersions that contain mineral and/or organic and/or organomineral solids and that react, when combined or when reacted with an aqueous liquid, to a solid in a cement-type initiation reaction. The invention also relates to the use of these materials as technical, medical-technical and/or pharmaceutical products, especially as bone cements, bone replacement materials, bone glues, dental filling materials and implantable active ingredient carriers.Type: ApplicationFiled: August 16, 2017Publication date: November 30, 2017Applicant: InnoTERE GmbHInventor: Berthold NIES
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Patent number: 9764057Abstract: The invention relates to implant materials that are based on hydraulic cements in the form of one or more pastes, suspensions or dispersions that contain mineral and/or organic and/or organomineral solids and that react, when combined or when reacted with an aqueous liquid, to a solid in a cement-type initiation reaction. The invention also relates to the use of these materials as technical, medical-technical and/or pharmaceutical products, especially as bone cements, bone replacement materials, bone glues, dental filling materials and implantable active ingredient carriers.Type: GrantFiled: June 6, 2008Date of Patent: September 19, 2017Assignee: InnoTERE GmbHInventor: Berthold Nies
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Patent number: 9572668Abstract: The invention relates to an implant and a set for producing an implant and their uses. Furthermore, the invention describes a method of making an implant as per the invention. An implant for producing bone implants with improved mechanical characteristics, especially with adjustable mechanical characteristics, is provided via the invention. The implant as per the invention made up of a fiber composite material contains resorbable mineral bone cement as the matrix material, to which reinforcing, long metal fibers and/or endless metallic fibers with an aspect ratio of at least 100:1 are added in the form of at least one fiber structure that provides a framework and that preforms the contour of the implant.Type: GrantFiled: April 11, 2013Date of Patent: February 21, 2017Assignee: Innotere GmbHInventors: Berthold Nies, Sophie Rössler, Sandra Storch, Chokri Cherif, Ezzeddine Laourine
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Patent number: 8974541Abstract: The invention relates to a bone implant which comprises a magnesium-containing metallic material having a reduced corrosion rate and inorganic bone cement, and to methods and a kit for producing the bone implant. With a method according to the invention, it is possible to obtain a bone implant which comprises inorganic bone cement and a magnesium-containing metallic material with a corrosion-inhibiting coating which contains magnesium-ammonium phosphates. In the method according to the invention, a magnesium-containing metallic material, of which the surface has a magnesium oxide layer and/or a magnesium salt layer, is combined with inorganic bone cement in order to generate a solid composite material that comprises the inorganic bone cement and the magnesium-containing metallic material.Type: GrantFiled: June 15, 2011Date of Patent: March 10, 2015Assignee: InnoTERE GmbHInventors: Berthold Nies, Stefan Glorius
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Patent number: 8834845Abstract: A bioactive PMMA (polymethylmethacrylate) bone cement contains a powder component and a reactive monomer liquid, wherein the powder component and the reactive monomer liquid when mixed with one another react with one another and form a polymer-based solid material. The powder component contains particulate polymer powder of polymethylmethacrylates; a radical starter; and anionic copolymer nanoparticles. The anionic copolymer nanoparticles are distributed in nano-particulate form within the particulate powder component or coated as a film on particles of the particulate polymer powder.Type: GrantFiled: March 31, 2010Date of Patent: September 16, 2014Assignee: InnoTERE GmbHInventors: Berthold Nies, Werner Siol
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Patent number: 8829073Abstract: An implant material on the basis of a polymer system has a first component and a second component that react with one another when mixed to form a polymer-based solid. The first component is a paste that contains at least one biocompatible polymer powder and a starter component for initiating a polymerization reaction upon mixing, wherein the paste has a carrier liquid, wherein under normal conditions in the carrier liquid the at least one biocompatible polymer powder does not dissolve or significantly swell and the starter component remains stable until mixing with the second component of the polymer system. The second component of the polymer system contains at least one reactive organic liquid or a solution or a suspension of a reactive organic liquid and of a polymer.Type: GrantFiled: March 27, 2008Date of Patent: September 9, 2014Assignee: InnoTERE GmbHInventor: Berthold Nies
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Patent number: 8741982Abstract: A bioactive and osteoconductive bone cement is produced from polyacrylates or polymethylacrylates by addition of small amounts of polymerizable monomers containing anionic groups which cause the cement surface to mineralize after being incubated in simulated body fluid. The obtained mineralized layers contain calcium phosphate phases such that the formation of fibrous intermediate layers is prevented once the bone cement has been implanted in bones. Optionally, other additives, e.g. biocompatible calcium salts, biocompatible buffering substances, or x-ray contrast agents, antibiotics, antimicrobial agents, and/or anti-inflammatory agents can be added in order to improve the properties of the cement for individual purposes. The bone cement can be used for anchoring prosthesis components in the bone, stiffening bones, filling and reconstructing all types of bone defects, as dowels for bone screws, or as an implant material for anchoring screws and other implants used for osteosynthesis.Type: GrantFiled: May 9, 2006Date of Patent: June 3, 2014Assignee: InnoTERE GmbHInventor: Berthold Nies
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Patent number: 8540815Abstract: The invention relates to a preparation for a magnesium ammonium phosphate cement. There is provided a preparation comprising (a) a magnesium calcium phosphate of the formula MgxCay(PO4)2Oz, wherein x+y?4, x>1, y>0, z=x+y?3 and z?0; (b) an ammonium salt; and (c) water; wherein the ammonium salt and the water can be present partially or completely as an aqueous solution of the ammonium salt.Type: GrantFiled: February 18, 2009Date of Patent: September 24, 2013Assignee: InnoTERE GmbHInventor: Uwe Gbureck
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Publication number: 20130150978Abstract: The invention relates to a bone implant which comprises a magnesium-containing metallic material having a reduced corrosion rate and inorganic bone cement, and to methods and a kit for producing the bone implant. With a method according to the invention, it is possible to obtain a bone implant which comprises inorganic bone cement and a magnesium-containing metallic material with a corrosion-inhibiting coating which contains magnesium-ammonium phosphates. In the method according to the invention, a magnesium-containing metallic material, of which the surface has a magnesium oxide layer and/or a magnesium salt layer, is combined with inorganic bone cement in order to generate a solid composite material that comprises the inorganic bone cement and the magnesium-containing metallic material.Type: ApplicationFiled: June 15, 2011Publication date: June 13, 2013Applicant: InnoTERE GMBHInventors: Berthold Nies, Stefan Glorius
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Publication number: 20120271431Abstract: The invention relates to methods for producing a partial or complete bioactive coating of an iron and/or zinc based metal implant material with calcium phosphates, a bioactively coated iron and/or zinc based metal implant, which is partially or completely coated with calcium phosphates, and bone implants containing an implant material according to the invention. In order to produce the coating according to the invention, iron and/or zinc based metal implant materials are brought in contact with acidic aqueous solutions, which have a pH value of 6.0 or less and contain calcium phosphates, whereby a calcium phosphate layer is deposited on the surface of the implant materials. The iron and/or zinc based metal implant materials, which are used in methods according to the invention, are materials consisting of base iron alloys or pure iron or materials that contain other substances, which are coated with pure iron, with a base iron alloy and/or with zinc.Type: ApplicationFiled: September 3, 2010Publication date: October 25, 2012Applicant: INNOTERE GMBHInventors: Berthold Nies, Stefan Glorius, Sophie Rössler
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Publication number: 20120191214Abstract: The invention relates to implant materials that are based on hydraulic cements in the form of one or more pastes, suspensions or dispersions that contain mineral and/or organic and/or organomineral solids and that react, when combined or when reacted with an aqueous liquid, to a solid in a cement-type initiation reaction. The invention also relates to the use of these materials as technical, medical-technical and/or pharmaceutical products, especially as bone cements, bone replacement materials, bone glues, dental filling materials and implantable active ingredient carriers.Type: ApplicationFiled: June 6, 2008Publication date: July 26, 2012Applicant: InnoTERE GmbHInventor: Berthold Nies
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Publication number: 20110054392Abstract: An implant material on the basis of a polymer system has a first component and a second component that react with one another when mixed to form a polymer-based solid. The first component is a paste that contains at least one biocompatible polymer powder and a starter component for initiating a polymerization reaction upon mixing, wherein the paste has a carrier liquid, wherein under normal conditions in the carrier liquid the at least one biocompatible polymer powder does not dissolve or significantly swell and the starter component remains stable until mixing with the second component of the polymer system. The second component of the polymer system contains at least one reactive organic liquid or a solution or a suspension of a reactive organic liquid and of a polymer.Type: ApplicationFiled: March 27, 2008Publication date: March 3, 2011Applicant: INNOTERE GMBHInventor: Berthold Nies
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Publication number: 20110028568Abstract: The invention relates to a preparation for a magnesium ammonium phosphate cement. There is provided a preparation comprising (a) a magnesium calcium phosphate of the formula MgxCay(PO4)2Oz, wherein x+y?4, x>1, y>0, z=x+y?3 and z?0; (b) an ammonium salt; and (c) water; wherein the ammonium salt and the water can be present partially or completely as an aqueous solution of the ammonium salt.Type: ApplicationFiled: February 18, 2009Publication date: February 3, 2011Applicant: INNOTERE GMBHInventor: Uwe Gbureck
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Publication number: 20100272649Abstract: A bioactive PMMA (polymethylmethacrylate) bone cement contains a powder component and a reactive monomer liquid, wherein the powder component and the reactive monomer liquid when mixed with one another react with one another and form a polymer-based solid material. The powder component contains particulate polymer powder of polymethylmethacrylates; a radical starter; and anionic copolymer nanoparticles. The anionic copolymer nanoparticles are distributed in nano-particulate form within the particulate powder component or coated as a film on particles of the particulate polymer powder.Type: ApplicationFiled: March 31, 2010Publication date: October 28, 2010Applicant: InnoTERE GMBHInventors: Berthold Nies, Werner Siol
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Publication number: 20080194729Abstract: The invention relates to a novel bioactive and osteoconductive bone cement and a method for producing the same from polyacrylates or polymethylacrylates by addition of small amounts of polymerizable monomers containing anionic groups which cause the cement surface to mineralize after being incubated in simulated body fluid and in which the obtained mineralized layers contain calcium phosphate phases such that the formation of fibrous intermediate layers is prevented once the bone cement has been implanted in bones. Optionally, other additives, e.g. biocompatible calcium salts, and/or biocompatible buffering substances, or x-ray contrast agents, antibiotics, antimicrobial agents, and/or anti-inflammatory agents can be added in order to improve the properties of the cement for individual purposes.Type: ApplicationFiled: May 9, 2006Publication date: August 14, 2008Applicant: InnoTERE GmbHInventor: Berthold Nies