Abstract: Nasal compositions, comprising an aqueous solution containing caffeine and/or theobromine in a total concentration of up to about 0.5 percent (w/v) and an aqueous carrier having a pH of about 6-8 and comprising physiologically acceptable salts of sodium, potassium and calcium. The nasal composition when used as a nasal spray or as nasal drops or irrigation fluid is able to clean the nasal passages and to stimulate nasal mucociliary clearance and, in contrast to nasal decongestants, may be used on a daily-basis for a period longer than 5 days.
Type:
Grant
Filed:
November 21, 2019
Date of Patent:
August 25, 2020
Assignees:
Innotesto BVBA, Veramed BV
Inventors:
Franciscus Wilhelmus Henricus Maria Merkus, Bart Merkus
Abstract: An oromucosal solution comprising about 1-8% (w/v) apomorphine or a pharmaceutical acceptable salt thereof solubilised in a non-aqueous carrier containing at least about 50% (v/v) of propylene glycol. A small volume (25-250 ?L) of said solution containing about 1-12 mg apomorphine may be administered upon demand to treat motor fluctuations during off periods in patients suffering from Parkinson's disease. The solution may also be used for the treatment of sexual dysfunction.
Type:
Grant
Filed:
November 7, 2016
Date of Patent:
August 22, 2017
Assignee:
INNOTESTO BVBA
Inventor:
Franciscus Wilhelmus Henricus Maria Merkus
Abstract: Solutions of testosterone for oromucosal administration providing an increase in serum testosterone levels in subjects deficient in endogenous testosterone levels, and therapeutic methods for providing an increase in serum testosterone levels and methods for treating a disease or a symptom associated with deficient endogenous levels of testosterone.
Type:
Grant
Filed:
August 9, 2011
Date of Patent:
November 22, 2016
Assignee:
INNOTESTO BVBA
Inventor:
Franciscus Wilhelmus Henricus Maria Merkus
Abstract: Nasal compositions, comprising an aqueous solution containing caffeine and/or theobromine in a total concentration of up to about 0.5% (w/v) and an aqueous carrier having a pH of about 6-8 and comprising physiologically acceptable salts of sodium, potassium and calcium. The nasal composition when used as a nasal spray or as nasal drops or irrigation fluid is able to clean the nasal passages and to stimulate nasal mucociliary clearance and, in contrast to nasal decongestants, may be used on a daily-basis for a period longer than 5 days.
Type:
Application
Filed:
October 30, 2014
Publication date:
September 22, 2016
Applicants:
INNOTESTO BVBA, Veramed B.V.
Inventors:
Franciscus Wilhelmus Henricus Maria Merkus, Bart Merkus
Abstract: The present invention relates to low dose estradiol solutions for oromucosal administration suitable in replacement therapy or suppletion of low estradiol levels and also for preventing, alleviating or treating symptoms associated with low endogenous levels of estradiol in female subjects.
Type:
Grant
Filed:
January 4, 2013
Date of Patent:
August 2, 2016
Assignee:
INNOTESTO BVBA
Inventor:
Franciscus Wilhelmus Henricus Maria Merkus
Abstract: An oromucosal solution comprising about 1-8% (w/v) apomorphine or a pharmaceutical acceptable salt thereof solubilised in a non-aqueous carrier containing at least about 50% (v/v) of propylene glycol. A small volume (25-250 ?L) of said solution containing about 1-12 mg apomorphine may be administered upon demand to treat motor fluctuations during off periods in patients suffering from Parkinson's disease. The solution may also be used for the treatment of sexual dysfunction.
Type:
Application
Filed:
September 27, 2013
Publication date:
October 1, 2015
Applicant:
INNOTESTO BVBA
Inventor:
Franciscus Wilhelmus Henricus Maria Merkus
Abstract: Solutions of testosterone for oromucosal administration providing an increase in serum testosterone levels in subjects deficient in endogenous testosterone levels, and therapeutic methods for providing an increase in serum testosterone levels and methods for treating a disease or a symptom associated with deficient endogenous levels of testosterone.
Type:
Application
Filed:
August 9, 2011
Publication date:
June 6, 2013
Applicant:
INNOTESTO BVBA
Inventor:
Franciscus Wilhelmus Henricus Maria Merkus