Abstract: A medicament delivery device (1) comprises an actuation mechanism by successive operation of which a predetermined number of unit doses of medicament can be dispensed. The device includes a locking mechanism for preventing further operation of the actuation mechanism after dispensing of said predetermined number of unit doses. The locking mechanism comprises a resilient member (51), a formation (18) with which the resilient member (51) is engageable to disable operation of the actuation mechanism, and a barrier member (20) that prevents engagement of the resilient member (51) and the formation (18) until said predetermined number of unit doses has been dispensed. The device (1) may be a dry powder inhaler.

Abstract: The present invention relates to suspension formulations, especially those for delivering a pharmaceutically active agent in aerosol form using a spray or aerosol device, such as a pressurized metered dose inhaler (pMDI). The formulations may be for pulmonary, nasal, buccal or topical administration, but are preferably for pulmonary inhalation.

Abstract: A medicament delivery device (1) comprises an actuation mechanism by successive operation of which a predetermined number of unit doses of medicament can be dispensed. The device includes a locking mechanism for preventing further operation of the actuation mechanism after dispensing of said predetermined number of unit doses. The locking mechanism comprises a resilient member (51), a formation (18) with which the resilient member (51) is engageable to disable operation of the actuation mechanism, and a barrier member (20) that prevents engagement of the resilient member (51) and the formation (18) until said predetermined number of unit doses has been dispensed. The device (1) may be a dry powder inhaler.

Abstract: A dry powder inhaler (1) is disclosed comprising first and second medicament reservoirs (2, 2a) and respective rotatable first and second metering members (5, 5a), which are urged into sealing engagement with the respective medicament reservoir (2, 2a) by a compression spring (8) located between the metering members (5, 5a). The inhaler (1) includes an actuator by which the first and second metering members (5, 5a) are rotated in unison from a metering position to a dispensing position. The actuator acts upon the first and second metering members (5, 5a) via a wheel (9) mounted between the first and second metering members (5, 5a). The first and second metering members (5, 5a) are provided with sockets (51) that receive the respective ends of the compression spring (8).

Abstract: A dry powder inhaler comprises an airway (1) along which, in use, air is drawn from an upstream, inlet end (2) to a downstream, outlet end (3). The airway (1) includes a medicament presentation region (4) at which, in use, a dose of medicament is presented to the airway (1), a primary air inlet (10), and a barrel (5) extending from the medicament presentation region (4) to the outlet end (3) of the airway (1). The inlet end of the barrel (5) is of reduced internal dimension relative to the medicament presentation region (4) and relative to the outlet end of the barrel (5), such that the inlet end of the barrel (5) constitutes a constriction of the airway (1). At least one secondary air inlet (11) is disposed such that, in use, air enters the airway (1) from the secondary air inlet (11) in a direction that is substantially orthogonal to the direction of flow of air along said barrel (5).

Abstract: A dry powder inhaler comprises at least one medicament reservoir and a closure member engaged with the reservoir so as to close an opening therein. A surface of the reservoir adjacent the opening and a surface of the closure member are in abutment, either directly or via a seal member interposed between the reservoir and the closure member. At least one abutting surface is formed with a projection that increases the contact pressure between said surfaces, thereby improving the seal between them and reducing the potential for ingress of moisture between said surfaces into the reservoir.

Abstract: The disclosure relates to a medicament delivery assembly that has a mouthpiece provided with an air amplifier and a primer source, where the mouthpiece and the air amplifier are each connected to the primer source via an actuatable valve. The air amplifier is also provided with a medicament extraction tube such that when the actuatable valve is opened, the primer source is activated and causes air to flow to the air amplifier. There is also described a method of administering a medicament using such a medicament delivery assembly.

Abstract: A dose counter mechanism is suitable for use with a medicament delivery device. The dose counter mechanism comprises a rollable tape (20) provided with indicia (22), a tape housing (10) and a tape collector spool (40). The tape housing comprises a tape dispenser housing (14) within which, in use, a roll (24) of the tape is inserted and a tape collector spool housing (16) within which, in use, the tape collector spool is mounted. The tape dispenser housing and the tape collector spool housing are connected by a tape display area (15).

Abstract: The present invention relates to suspension formulations, especially those for delivering a pharmaceutically active agent in aerosol form using a spray or aerosol device, such as a pressurised metered dose inhaler (pMDI). The formulations may be for pulmonary, nasal, buccal or topical administration, but are preferably for pulmonary inhalation.

Abstract: There is described a medicament delivery device which comprises a medicament reservoir, a medicament delivery passage and a metering member adapted to transfer a measured dose of medicament from the medicament reservoir to the delivery passage characterized in that the device is provided with a moisture proof barrier. The medicament delivery device is especially suited for use as an inhaler. There is therefore also described an inhaler which provides improved airflow for the dispersion of medicament, and a method of treating patients suffering from a respiratory disorder.

Abstract: A delivery device, e.g. an inhaler, includes a rotatable metering member adapted to dispense a measured amount of material, a material delivery passage and a material delivery orifice and at least one actuator member adapted to move the metering member from a material retaining position to a material dispensing position. In a magazine including a plurality of metering members, the actuator and metering members may operate in a radial direction. A plurality of rotatable magazines may be utilized in the delivery device. The delivery device may be used to deliver a single or a combination therapy.

Abstract: An inhaler includes a first body member and a second body member fit closely together to form an inhaler body, and an outlet. The first body member has a medicament chamber containing a unit dose of powdered medicament. A seal such as a foil strip seals the medicament chamber and extends outwardly of the inhaler body. In use, one end of the seal can be grasped by a user and withdrawn, fully or partially, from the inhaler body, to release the powdered medicament from the medicament chamber. The second body member includes a medicament collection well in which the medicament is collected upon its release from the medicament chamber. The medicament collection well forms part of an airway connecting into the outlet. In use, air can be drawn by inhalation at the outlet to entrain the powder medicament in the collection well for inhalation by a user.

Abstract: A dry powder inhaler (1) is disclosed comprising first and second medicament reservoirs (2, 2a) and respective rotatable first and second metering members (5, 5a), which are urged into sealing engagement with the respective medicament reservoir (2, 2a) by a compression spring (8) located between the metering members (5, 5a). The inhaler (1) includes an actuator by which the first and second metering members (5, 5a) are rotated in unison from a metering position to a dispensing position. The actuator acts upon the first and second metering members (5, 5a) via a wheel (9) mounted between the first and second metering members (5, 5a). The first and second metering members (5, 5a) are provided with sockets (51) that receive the respective ends of the compression spring (8).

Abstract: The present invention relates to suspension formulations, especially those for delivering a pharmaceutically active agent in aerosol form using a spray or aerosol device, such as a pressurised metered dose inhaler (pMDI). The formulations may be for pulmonary, nasal, buccal or topical administration, but are preferably for pulmonary inhalation.

Abstract: A dry powder inhaler comprises at least one medicament reservoir containing a bulk quantity of a powdered medicament, and a metering mechanism by which unit doses of said medicament can be dispensed from the medicament reservoir for inhalation by a user of the inhaler. The at least one medicament reservoir is formed in polyester material. Penetration of moisture through the walls of the medicament reservoir is considerably reduced.

Abstract: A dry powder inhaler comprises at least one medicament reservoir and a closure member engaged with the reservoir so as to close an opening therein. A surface of the reservoir adjacent the opening and a surface of the closure member are in abutment, either directly or via a seal member interposed between the reservoir and the closure member. At least one abutting surface is formed with a projection that increases the contact pressure between said surfaces, thereby improving the seal between them and reducing the potential for ingress of moisture between said surfaces into the reservoir.

Abstract: There is described a bimodal pharmaceutical composition comprising effective amounts of a first active ingredient which substantially comprises a coarse fraction and a second active ingredient which substantially comprise a fine fraction characterized in that the coarse fraction possesses a greater mass median aerodynamic diameter than the fine fraction. There is also described a method of delivering a therapeutically effective amount of a substantially fine active ingredient to the lung of a patient by co-administration with a substantially coarse active ingredient.

Abstract: A delivery device, e.g. an inhaler, comprises a rotatable metering member adapted to dispense a measured amount of material, a material delivery passage and a material delivery orifice and at least one actuator member adapted to move the metering member from a material retaining position to a material dispensing position. In a magazine comprising a plurality of metering members, the actuator and metering members may operate in a radial direction. A plurality of rotatable magazines may be utilized in the delivery device. The delivery device may be used to deliver a single or a combination therapy.

Abstract: A delivery device, e.g. an inhaler, comprises a rotatable metering member adapted to dispense a measured amount of material, a material delivery passage and a material delivery orifice and at least one actuator member adapted to move the metering member from a material retaining position to a material dispensing position. In a magazine comprising a plurality of metering members, the actuator and metering members may operate in a radial direction. A plurality of rotatable magazines may be utilized in the delivery device. The delivery device may be used to deliver a single or a combination therapy.