Abstract: Clamp or clip on tensioning attachments, devices, apparatus and methods that mount to a toilet water tank reservoir. The tensioning attachments place downward pressure and tension on the toilet handle arm inside of the tank to prevent the internal flapper from being stuck in a raised position which causes the toilet to be constantly running after being flushed and also keeping tension on the handle arm which keeps the arm rigid not allowing it to loosen which in turn can cause the flapper chain to get hung up in the arm when the arm is lose causing the flapper not to seal as intended. Cleaner adapters can hang from the tensioner devices to clean water inside of the toilet bowl.

Abstract: A disposable inverted dispensing system for distributing a fluid for use in a shower is disclosed. The dispensing system includes a removable hooking device that is attachable to a surface which is exposable to moist conditions. A hook integral to the removable hooking device extends from the hooking device on a side opposite the surface when the hooking device is attached to the surface. A deformable container for containing the fluid has an upper portion and a lower portion. The upper portion defines a through-hole through the container, and the lower portion forms a container mouth through which the fluid is flowable. A dispensing valve and/or a cap is disposed over the mouth of the container for controlling the flow of the fluid. The container is positionable on the hooking device with the hook extending through the through-hole formed by the upper portion of the container so that the container hangs down from the hooking device.

Abstract: A disposable inverted dispensing system for distributing a fluid for use in a shower is disclosed. The dispensing system includes a removable hooking device that is attachable to a surface which is exposable to moist conditions. A hook integral to the removable hooking device extends from the hooking device on a side opposite the surface when the hooking device is attached to the surface. A deformable container for containing the fluid has an upper portion and a lower portion. The upper portion defines a through-hole through the container, and the lower portion forms a container mouth through which the fluid is flowable. A dispensing valve and/or a cap is disposed over the mouth of the container for controlling the flow of the fluid. The container is positionable on the hooking device with the hook extending through the through-hole formed by the upper portion of the container so that the container hangs down from the hooking device.

Abstract: The present invention relates to the compositions, methods, and applications of a novel approach to selective cellular targeting. The purpose of this invention is to enable the selective delivery and/or selective activation of effector molecules to target cells for diagnostic or therapeutic purposes. The present invention relates to multi-functional prodrugs or targeting vehicles wherein each functionality is capable of enhancing targeting selectivity, affinity, intracellular transport, activation or detoxification. The present invention also relates to ultra-low dose, multiple target, multiple drug chemotherapy and targeted immunotherapy for cancer treatment.

Abstract: The present invention provides a protector pad particularly adapted for use by volleyball players and the like comprising an outer section, a substantially flat inner section comprising a synthetic polymer, and a unitary attachment strap which, in one embodiment of the present invention, is integrally incorporated with the outer section. The attachment strap extends over the lower ⅔ of the pad such that the strap is positioned below the knee or elbow joint of the wearer, thus permitting the wearer's knee or elbow to be unrestrictedly flexed when the pad is attached. A pad according to the present invention protects the wearer's knee or elbow joint from contact with a hard surface, while simultaneously reducing friction between the pad and a contacting surface, permitting the wearer's elbow or knee to easily slide when the padded joint contacts the ground or other hard surface.

Abstract: Disclosed are novel prodrugs represented by the following structural formula: 1

Abstract: Disclosed are novel prodrugs represented by the following structural formula; Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.

Abstract: Disclosed are novel prodrugs represented by the following structural formula: Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.

Abstract: The composition and methods of synthesis of phosphorus prodrugs are described. These methods can be used to convert negatively charged phosphorus bearing drugs into neutrally charged; lipid soluble prodrugs which are able to passively diffuse into cells and into tissues in vivo. Prodrugs for a variety of antiviral and anti-leukemic agents are described.

Abstract: Disclosed are novel prodrugs represented by the following structural formula: ##STR1## Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.

Abstract: Disclosed are novel prodrugs represented by the following structural formulas: ##STR1## Z is oxygen or sulfur; n is 1 or 2; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a group which can be metabolized in vivo to a give a modified A such that the phosphoester bond (modified A)--O undergoes cleavage in vivo. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.

Abstract: The composition and methods of synthesis of phosphorus prodrugs are described. These methods can be used to convert negatively charged phosphorous bearing drugs into neutrally charged; lipid soluble prodrugs which are able to passively diffuse into cells and into tissues in vivo. Prodrugs for a variety of antiviral and anti-leukemic agents are described.

Abstract: The composition, synthesis, and applications of tumor associated protease activated prodrugs of phosphoramide mustard, isophosphoramide mustard and analogs with detoxification functionalities are described. These drugs release a cytotoxic phosphoramide mustard analog following activation by tumor associated proteases and esterases. The general structure for these drugs is: ##STR1## Wherein R1 is a beta-X-ethyl-amino group which may optionally bear substituents on the nitrogen or carbon atoms; wherein X is a good leaving group such as a halogen; R2 is a beta-X-ethyl-amino group which may optionally bear substituents on the nitrogen or carbon atoms; or an amino group (NH.sub.2) which may optionally be substituted. Wherein A is a benzyloxy derivative with one or more acyloxy or acylamino groups in para or ortho portions relative to the phosphoester; and wherein the acyloxy or acylamino groups are not (substituted or unsubstituted) p-guanidino-benzoyloxy groups or p-guanidino-benzoylamino groups.

Abstract: The composition and methods of synthesis of phosphorus prodrugs are described. These methods can be used to convert negatively charged phosphorous bearing drugs into neutrally charged; lipid soluble prodrugs which are able to passively diffuse into cells and into tissues in vivo. Prodrugs for a variety of antiviral and anti-leukemic agents are described.