Patents Assigned to INNOVATION PHARMACOLOGY RESEARCH OOO ("IPHAR")
  • 1,4-benzodiazepin-2-one derivatives and use thereof
    Patent number: 11358939
    Abstract: The invention relates to novel compounds that are derivatives of 1,4-benzodiazepin-2-one, having the general formula I: and being limited to structural variants 1-6: on condition that: a) structures 1 (R1=Br, R4=F), 3 (R1=OCF3, R4=H), 5 (R1=NO2, R4=Cl) and 6 (R1=NO2, R4=F) have the following substituents R2 and R3: R2=H, CH2COCH3, CH2COOCH3, CH2CONHNH2; R3=OAlk, NHAr, where Alk=C2H5, C3H7, C4H9, (CH2)2OH, (CH2)2OCH3, R5=o-, m-, p-COCH3, Cl, F, Br, NO2, CF3; b) structure 2 (R1=Cl, R4=H) has the following substituents R2 and R3: if R2=H, then R3=OAlk, NHAr, where Alk=(CH2)2OCH3, R5=m-, p-COCH3, o-, m-, p-F, Br, CF3; ?if R2=CH2COCH3, CH2COOCH3, CH2CONHNH2, then R3=OAlk, NHAr, where Alk=C2H5, C3H7, C4H9, (CH2)2OH, (CH2)2OCH3, R5=o-, m-, p-COCH3, Cl, F, Br, NO2, CF3; c) structure 4 (R1=NO2, R4=H) has the following substituents R2 and R3: if R2=H, then R3=OAlk, NHAr, where Alk=(CH2)2OCH3, R5=o-, m-, p-COCH3, Cl, F, Br,
    Type: Grant
    Filed: December 29, 2018
    Date of Patent: June 14, 2022
    Assignee: INNOVATION PHARMACOLOGY RESEARCH OOO (IPHAR)
    Inventors: Viktor Ivanovich Pavlovsky, Veniamin Abramovich Khazanov, Sergey Aleksandrovich Stankevich
  • METHOD OF PRODUCING TRANSFORMED PLANT CELLS, CONTAINING RECOMBINANT HUMAN ALKALINE PHOSPHATASE, AND THE USE OF SAID TRANSFORMED PLANT CELLS, CONTAINING RECOMBINANT HUMAN ALKALINE PHOSPHATASE
    Publication number: 20210214738
    Abstract: The invention relates to food industry and medicine and describes the method of producing transformed plant cells, containing recombinant human alkaline phosphatase, and their use for maintaining the homeostasis of gastrointestinal tract as an agent, regulating gastrointestinal tract microflora and the immune system.
    Type: Application
    Filed: January 29, 2019
    Publication date: July 15, 2021
    Applicant: INNOVATION PHARMACOLOGY RESEARCH OOO (?IPHAR?)
    Inventors: Natalya Anatolyevna SHMYKOVA, Roman Alexandrovich KOMAKHIN, Sergey Aleksandrovich STANKEVICH, Veniamin Abramovich KHAZANOV
  • 1,4-BENZODIAZAPIN-2-ONE DERIVATIVES AND USE THEREOF
    Publication number: 20200361878
    Abstract: The invention relates to novel compounds that are derivatives of 1,4-benzodiazepin-2-one, having the general formula I: and being limited to structural variants 1-6: on condition that: a) structures 1 (R1?Br, R4?F), 3 (R1?OCF3, R4?H), 5 (R1?NO2, R4?Cl) and 6 (R1?NO2, R4?F) have the following substituents R2 and R3: R2?H, CH2COCH3, CH2COOCH3, CH2CONHNH2; R3=OAlk, NHAr, where Alk=C2H5, C3H7, C4H9, (CH2)2OH, (CH2)2OCH3, R5=o-, m-, p-COCH3, Cl, F, Br, NO2, CF3; b) structure 2 (R1?Cl, R4?H) has the following substituents R2 and R3: if R2?H, then R3=OAlk, NHAr, where Alk=(CH2)2OCH3, R5=m-, p-COCH3, o-, m-, p-F, Br, CF3; if R2?CH2COCH3, CH2COOCH3, CH2CONHNH2, then R3=OAlk, NHAr, where Alk=C2H5, C3H7, C4H9, (CH2)2OH, (CH2)2OCH3, R5=o-, m-, p-COCH3, Cl, F, Br, NO2, CF3; c) structure 4 (R1?NO2, R4?H) has the following substituents R2 and R3: if R2?H, then R3=OAlk, NHAr, where Alk=(CH2)2OCH3, R5=o-, m
    Type: Application
    Filed: December 29, 2018
    Publication date: November 19, 2020
    Applicant: INNOVATION PHARMACOLOGY RESEARCH OOO ("IPHAR")
    Inventors: Viktor Ivanovich PAVLOUSKY, Veniamin Abramovich KHAZANOV, Sergey Aleksandrovich STANKEVICH