Abstract: The invention concerns compounds represented by general formula (I) wherein: Z represents a sulfur or oxygen atom; the groups R1 and R2, identical or different, represent each a alkyl group or an alkenyl group; X represents a CO, a CO2, an SO, or an SO2 and the group R represents an alkyl, aryl, alkenyl, or aralkyl group, provided that when Z represents an oxygen atom, X an SO2 and R a group (a), R1 and R2 do not both represent the methyl group. The invention also concerns methods for preparing said compounds, pharmaceutical compositions containing them and their use as promoter of &ggr;-aminobutyric acid and as medicine particularly designed for treating nervous disorders.
Type:
Grant
Filed:
June 26, 2002
Date of Patent:
December 9, 2003
Assignees:
Centre National de la Recherche Scientifique (CNRS), Innovationsagentur GmbH, Universite de Bern
Inventors:
Robert Dodd, Ahmed El Hadri, Jean-Paul Pierre Potier, Werner Sieghart, Frantisek Jursky, Roman Furtmuller, Erwin Sigel, Urs Thomet
Abstract: The invention concerns compounds of general formula (I) wherein: Z represents a sulphur or oxygen atom, NH, N-alkyl or Nboc; group R′, identical or different, represent each a hydrogen atom, a OCH3 group or a OCH2O group; group R″ represents a hydrogen or a CH3 group; group X represents a carbonyl, sulphonyl or CO2 group; and group R represents an alkyl, aryl, alkenyl or aralkyl group. The invention also concerns the preparation of said compounds, pharmaceutical compositions containing them and their use for stimulating &ggr;-amino-butyric acid activity and as medicine for treating nervous disorders.
Type:
Grant
Filed:
August 15, 2002
Date of Patent:
November 18, 2003
Assignees:
Centre National de la Recherche Scientifique (CNRS), Universite de Bern, Innovationsagentur GmbH
Inventors:
Robert Dodd, Rodolphe Razet, Pierre Jean-Paul Potier, Werner Sieghart, Frantisek Jursky, Roman Furtmuller, Erwin Sigel, Urs Thomet