Abstract: The invention relates to cDNA libraries obtained from Tammar wallaby (Macropus eugenii) mammary gland tissue at different times (including day 23 pregnancy, day 130 lactation, and day 260 lactation). Lactation-associated polypeptides were identified from these cDNA libraries, and bovine homologues of the wallaby proteins are also disclosed. The proteins have a range of activities including anti-apoptotic activity, pro- or anti-inflammatory activity, cathelicidin anti-microbial activity, induction of trefoil proteins (and protection of epithelial surfaces), increased cell proliferation, and induction of cell differentiation (and loss of pluripotency).
Type:
Application
Filed:
August 8, 2008
Publication date:
August 18, 2011
Applicants:
Dairy Australia Limited, Innovative Dairy Products PTY LTD, as trustee for the participants of The Cooperative Research Cente
Inventors:
Christophe Marc Lefevre, Elie Khalil, Julie Sharp, Karensa Menzies, Kevin Roy Nicholas, Paul Sheehy, Yvan Strahm, Lisa Riley, Peter Williamson, Kerry Daly, Matthew Robert Digby