Abstract: An electronic health care compliance assistance system includes a user device and a host station used by a health care provider. The user device generates voice messages to remind a user when and how to take or refill prescribed medications, to attend to other health matters, and to keep doctors' appointments. Compressed digital speech is used to generate clear and natural sounding voice messages. A health care provider uses the host station to compose messages and to store a database of speech messages and related data. Data are transferred from the host station to the user device to generate a regimen that is customized for the user. A queuing system is provided for messages relating to medications having common dosing times. A parameter is defined to permit adaptive rescheduling of messages when a user does not respond. The user device provides adaptive and interactive audible and visual prompts to alert the user when one or more messages are ready to be played.