Patents Assigned to Innovative Pharmacology Research OOO (IPHAR)
  • 2-acetyl-6-(2-(2-(4-bromobenzylidene)hydrazinyl)thiazole-4-yl)-3,7,9-trihydroxy-8,9b-dimethyldibenzo[,b,d]furan-1(9bh)-one exhibiting an inhibitory effect on human tyrosyl-DNA-phosphodiesterase 1 enzyme
    Patent number: 10399965
    Abstract: The present invention relates to the field of molecular biology, biochemistry and biotechnology, namely, to compound 2-acetyl-6-(2-(2-(4-bromobenzylidene)hydrazinyl) thiazole-4-yl)-3,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-1(9bh)-one, which is a hydrazine-thiazole derivative of usnic acid of formula I and which is able to inhibit the action of human tyrosyl-DNA-phosphodiesterase 1 enzyme. Technical result: increase in inhibitory action towards human tyrosyl-DNA-phosphodiesterase 1 enzyme (Tdp1) and increase in the number of inhibitors of this enzyme. 1 independent claim, 2 figures, 3 examples.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: September 3, 2019
    Assignee: INNOVATIVE PHARMACOLOGY RESEARCH OOO (IPHAR)
    Inventors: Olga Anatolyevna Luzina, Alexandra Leonidovna Zakharenko, Dmitry Nikolaevich Sokolov, Nariman Faridovich Salakhutdinov, Olga Ivanovna Lavrik, Veniamin Abramovich Khazanov
  • 2-ACETYL-6-(2-(2-(4-BROMOBENZYLIDENE)HYDRAZINYL)THIAZOLE-4-YL)-3,7,9-TRIHYDROXY-8,9B-DIMETHYLDIBENZO[B,D]FURAN-1(9BH)-ONE EXHIBITING AN INHIBITORY EFFECT ON HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME
    Publication number: 20190177315
    Abstract: The present invention relates to the field of molecular biology, biochemistry and biotechnology, namely, to compound 2-acetyl-6-(2-(2-(4-bromobenzylidene)hydrazinyl) thiazole-4-yl)-3,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-1(9bh)-one, which is a hydrazine-thiazole derivative of usnic acid of formula I and which is able to inhibit the action of human tyrosyl-DNA-phosphodiesterase 1 enzyme. Technical result: increase in inhibitory action towards human tyrosyl-DNA-phosphodiesterase 1 enzyme (Tdp1) and increase in the number of inhibitors of this enzyme.
    Type: Application
    Filed: July 24, 2017
    Publication date: June 13, 2019
    Applicant: INNOVATIVE PHARMACOLOGY RESEARCH OOO (IPHAR)
    Inventors: Olga Anatolyevna LUZINA, Alexandra Leonidovna ZAKHARENKO, Dmitry Nikolaevich SOKOLOV, Nariman Faridovich SALAKHUTDINOV, Olga Ivanovna; LAVRIK, Veniamin Abramovich KHAZANOV
  • Pyridopyrazindione derivative and its use as an antiulcer drug
    Patent number: 8440670
    Abstract: The invention relates to the fields of the chemical and pharmaceutical industry and medicine and concerns a novel compound which can be used as an antiulcer agent. The compound is 9 -(quinony-2)-2-p-ethoxyphenylethyl-4,5,6,7,8,9,10,11-octahydropyrido [1,2-a]pyrazindione-1,4 of formula (I), or pharmaceutically acceptable complex derivatives thereof. The compound can be used as an antiulcer agent.
    Type: Grant
    Filed: September 3, 2012
    Date of Patent: May 14, 2013
    Assignee: Innovative Pharmacology Research OOO (IPHAR)
    Inventors: Vladimir Grigorevich Granik, Valeriya Markovna Ljubchanskaya, Valery Aleksandrovich Parshin, Marina Alekseevna Kalinkina