Patents Assigned to INNOVATIVE TARGETING SOLUTIONS
  • Generating targeted sequence diversity in fusion proteins
    Patent number: 10233453
    Abstract: Methods of generating fusion protein variants are provided that comprise introducing sequence diversity at the junction region or regions in the fusion and allows for the generation of variants having a desired activity. Examples include immunoglobulins comprising a domain or polypeptide inserted into, or replacing, a CDR. Also provided are polynucleotides encoding a fusion protein and comprising two or more RSSs, and compositions and host cells comprising same, as well as fusion proteins variants produced by the described methods.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: March 19, 2019
    Assignee: INNOVATIVE TARGETING SOLUTIONS
    Inventors: Michael Gallo, Jaspal Singh Kang, Craig Robin Pigott