Abstract: A patient digital twin platform includes a clinical subsystem, a patient subsystem, and a performance capture system. The clinical subsystem generates physical therapy exercises for a patient. The patient subsystem directs the patient to perform the exercises generated by the clinical patient subsystem. The performance capture system captures measurement data, such as video, of the patient performing at least one physical therapy exercise prescribed by the clinical subsystem. The output of the performance capture system is input to a patient digital twin engine that updates a patient digital twin of the patient.