Abstract: Provided is a method for preventing or treating a wound or scar comprising administering to a subject in need thereof a pharmaceutical composition comprising benzbromarone as an active ingredient, wherein benzbromarone inhibits the function of heat shock protein 47 (HSP47), or inhibits the accumulation of collagen by reducing collagen overproduction cells.
Abstract: Provided is a method for preventing or treating a wound or scar comprising administering to a subject in need thereof a pharmaceutical composition comprising benzbromarone as an active ingredient, wherein benzbromarone inhibits the function of heat shock protein 47 (HSP47), or inhibits the accumulation of collagen by reducing collagen overproduction cells.
Abstract: The present invention relates to a heteroarylamidopyridinol derivative and a pharmaceutical composition comprising same as an active ingredient for prevention or treatment of an autoimmune disease, specifically, inflammatory bowel disease, rheumatoid arthritis, etc. The heteroarylamidopyridinol derivative exhibits an excellent effect of inhibiting TNF-?- or IL-6-induced monocyte adhesion to gut epithelial cells and is proven to have a therapeutic effect on inflammatory bowel disease and rheumatoid arthritis in vivo. Thus, the heteroarylamidopyridinol derivative can be advantageously used for treatment of an autoimmune disease, specifically, inflammatory bowel disease or rheumatoid arthritis.
Type:
Application
Filed:
September 24, 2020
Publication date:
October 13, 2022
Applicant:
INNOVO THERAPEUTICS INC.
Inventors:
Byeong-Seon Jeong, Jung-Ae Kim, Tae-gyu Nam