Abstract: A method and system for degreasing a kitchen ventilation system includes determining degreasing setpoint(s) for a degreasing time interval, injecting degreasing agent within the kitchen ventilation system during the degreasing time interval and operating subsystem(s) of the kitchen ventilation system in accordance with the degreasing set point(s). The method and system can also include sensing operating condition(s) within the kitchen ventilation system, determining degreasing parameter(s) based on the sensed operation(s) and injecting degreasing agent with the kitchen ventilation system according to the degreasing parameter(s). Operating condition(s) can also be tracked over time to schedule degreasing at a future time. Safe degreasing conditions can also be detected prior to any injection of the degreasing agent.