Patents Assigned to INOTEB
  • Method of preparing a biological glue able to coagulate simply by addition of calcium ions
    Patent number: 5985315
    Abstract: By placing a blood plasma in contact with a blood coagulation contact phase activator, before or during preparation of a fibrinogen-based biological glue, a preactivated biological glue is obtained which does not coagulate spontaneously but which is capable of coagulating in less than 5 minutes simply by the addition of calcium ions, without the addition of thrombin. The process has application to the field of surgery.
    Type: Grant
    Filed: December 30, 1997
    Date of Patent: November 16, 1999
    Assignee: Inoteb
    Inventors: Jean-Louis Patat, Olivier Delmas, Roland Schmitthaeusler
  • Device for filtration of cryoprecipitate and its application
    Patent number: 5911886
    Abstract: The present invention provides a device with a filter bag for separating a liquid phase from a suspended solid phase in a biological fluid.
    Type: Grant
    Filed: January 29, 1997
    Date of Patent: June 15, 1999
    Assignee: Inoteb
    Inventor: Olivier Marcel Joseph Delmas
  • Use of a porous calcium carbonate based material as support of a growth factor in the preparation of a bioabsorbable implant
    Patent number: 5711957
    Abstract: A method for treating a living organism includes fitting in the living organism a bioabsorbable implant. The bioabsorbable implant includes a support of porous calcium carbonate based material for supporting at least one growth factor. The calcium carbonate based support material forms an external wall of the support.
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: January 27, 1998
    Assignee: Inoteb
    Inventors: Jean-Louis Patat, Jean-Pierre Ouhayoun
  • Use of particles of a biocompatible and bioabsorbable calcium salt as active ingredient in the preparation of a medicinal product intended for the local treatment of bone demineralization diseases
    Patent number: 5618549
    Abstract: A method of treating a living organism having a disease associated with demineralization or mineralization defects of an existing bone by applying in a spongy portion of the bone or in a medullary canal of the bone at least one biocompatible and bioabsorbable calcium salt in the form of particles having dimensions less than 8 mm. The biocompatible and bioabsorbable calcium salt is an active ingredient for reinitiating bone remineralization and reconstruction of resorbed bone spans and increases bone density and bone mass.
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: April 8, 1997
    Assignee: Inoteb
    Inventors: Jean-Louis Patat, Yves Cirotteau
  • Device for producing a supernatant of activated thrombocytes, method for implementing the device and supernatant obtained
    Patent number: 5618663
    Abstract: A method for preparing platelet factors features a liquid that contains a suspension of thrombocytes being passed over a filter capable of retaining the thrombocytes. Thrombocytes are activated by an activating solution that is administered to the thrombocytes retained on the filter. A filtrate containing platelet factors in solution is separated by filtration while the thrombocytes are retained on the filter.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: April 8, 1997
    Assignees: Inoteb, Olivier Delmas
    Inventor: Olivier Delmas
  • Method of preparing a biological adhesive enriched with platelet factors, and application
    Patent number: 5589462
    Abstract: A method for the preparation of a platelet factor-enriched biological adhesive comprising freezing a platelet-enriched plasma and isolating a cryoprecipinate from the frozen platelet-enriched plasma is disclosed. Also disclosed is a method for biological adhesion employing the prepared biological adhesive.
    Type: Grant
    Filed: July 15, 1994
    Date of Patent: December 31, 1996
    Assignee: Inoteb
    Inventors: Jean-Louis Patat, Olivier Delmas, Roland Schmitthaeusler
  • Use of porous polycrystalline aragonite as a support material for in vitro culture of cells
    Patent number: 5480827
    Abstract: A three-dimensional solid support for the in vitro cultivation of cells consists essentially of porous polycrystalline aragonite in the form of a cylinder, sphere or plate. The support may be used to successively grow layers of different cells on the support, and is particularly useful for cultivating endothelial cells, fibroblasts and bone marrow cells.
    Type: Grant
    Filed: May 3, 1993
    Date of Patent: January 2, 1996
    Assignee: Inoteb
    Inventors: Genevieve Guillemin, Pascal Christel, Jean-Louis Patat, Alain Meunier
  • Bone prosthesis material containing calcium carbonate particles dispersed in a bioresorbable polymer matrix
    Patent number: 5433751
    Abstract: Bioresorbable bone prosthesis material containing particles of calcium carbonate, originating, for example, from coral skeleton, dispersed within a polymer matrix, the said particles being smaller than 1 mm in size and representing from 40 to 70% of the total weight, and the said polymer being a bioresorbable polymer.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: July 18, 1995
    Assignee: INOTEB
    Inventors: Pascal Christel, Su M. Li, Michel Vert, Jean-Louis Patat