Patents Assigned to INOVA Diagnostics, Inc.
  • DETECTING ANTIBODIES USING ANTIGENS
    Publication number: 20250085281
    Abstract: An example complex includes a solid support and at least two different types of antigens attached to the solid support. The complex includes a carrier protein attached to the solid support. At least one of the different types of antigens is attached to the carrier protein. The at least one of the different types of antigens is attached to the solid support through the carrier protein.
    Type: Application
    Filed: September 5, 2024
    Publication date: March 13, 2025
    Applicant: Inova Diagnostics, Inc.
    Inventors: Michael Mahler, Chelsea Bentow
  • Compositions and methods for the diagnosis of rheumatoid arthritis
    Patent number: 10684284
    Abstract: The present disclosure relates to the field of molecular biology and more specifically to methods for detecting anti-carbamylated protein (anti-CarP) antibodies in the serum of rheumatoid arthritis (RA) patients.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: June 16, 2020
    Assignees: Inova Diagnostics, Inc., Leiden University Medical Center
    Inventors: Michael Mahler, Leendert A. Trouw, Jan Wouter Drijfhout, Tom Huizinga, René Toes, Peter Van Veelen
  • Method for increasing specificity of diagnostic tests for autoimmune diseases
    Patent number: 10234453
    Abstract: Provided is a method for increasing the specificity of an antibody-based test to help in the diagnosis of autoimmune diseases by contacting a subject's sample with a blocking antigen prior to testing that is capable of binding to any interfering antibody present in the sample. More specifically, a method for increasing specificity of an antibody-based autoimmune disease assay comprising the steps of providing a sample from a subject, contacting the sample with a DFS70 derived antigen, reacting the sample with an autoimmune disease target and detecting antibodies to the autoimmune disease target is disclosed.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: March 19, 2019
    Assignee: Inova Diagnostics, Inc.
    Inventor: Michael Mahler
  • Compositions and methods for diagnosing patients with acute atherosclerotic syndrome
    Patent number: 8338117
    Abstract: The present invention is in the field of autoimmunity. More specifically, the present invention relates to the detection of autoantibodies to domain 4 of beta 2-glycoprotein I (?2-GPI) as an indicator for atherosclerosis.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: December 25, 2012
    Assignee: Inova Diagnostics, Inc.
    Inventors: G. Michael Iverson, Walter L. Binder, Gary L. Norman
  • METHOED FOR DETECTING CIRCULATING CARTILAGE OLIGOMERIC MATRIX PROTEIN IN THE DIAGNOSIS AND MONITORING OF CIRRHOSIS
    Publication number: 20120183981
    Abstract: The present invention is in the field of diagnostics, and in particular to the early diagnosis of liver cirrhosis in a patient not known to have liver cancer by detecting and measuring circulating cartilage oligomeric matrix protein (COMP) alone or in conjunction with one or more additional liver cirrhosis biomarkers in the biological fluid of a subject.
    Type: Application
    Filed: August 30, 2010
    Publication date: July 19, 2012
    Applicant: Inova Diagnostics, Inc.
    Inventors: Gary L. Norman, Zakera Shums
  • Compositions and methods for diagnosing patients with acute atherosclerotic syndrome
    Patent number: 7745146
    Abstract: The present invention is in the field of autoimmunity. More specifically, the present invention relates to the detection of autoantibodies to domain 4 of beta 2-glycoprotein I (?2-GPI) as an indicator for atherosclerosis.
    Type: Grant
    Filed: July 26, 2007
    Date of Patent: June 29, 2010
    Assignee: Inova Diagnostics, Inc.
    Inventors: G. Michael Iverson, Walter L. Binder, Gary L. Norman
  • Methods and assays for detecting GP73-specific autoantibodies
    Patent number: 7622268
    Abstract: The present invention provides a method for detecting autoantibodies in a subject which reacts with a GP73 antigen. Increased levels of GP73-specific autoantibodies in a sample from the subject which bind to GP73 antigen are indicative of liver disease in the subject.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: November 24, 2009
    Assignee: INOVA Diagnostics, Inc.
    Inventors: Gary L. Norman, Zakera Shums