Abstract: Disclosed herein is a composition comprising a recombinant nucleic acid sequence that encodes an antibody to a Zika viral antigen, and functional fragments thereof. The invention also relates to a composition comprising the combination of a first composition that elicits an immune response in a mammal against zika virus and a second composition comprising a recombinant nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof. In some instances, the nucleic acid molecule comprises a nucleotide sequence encoding an anti-ZIKV-Envelope (anti-ZIKV E) Protein antibody.
Type:
Grant
Filed:
September 19, 2017
Date of Patent:
March 12, 2024
Assignees:
The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc., The Wistar Institute of Anatomy and Biology
Inventors:
David Weiner, Karuppiah Muthumani, Jian Yan
Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets an immune checkpoint molecule. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
Type:
Grant
Filed:
May 5, 2017
Date of Patent:
February 13, 2024
Assignees:
The Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology, Inovio Pharmaceuticals
Inventors:
David B. Weiner, Kar Muthumani, Niranjan Sardesai
Abstract: An electroporation device with a needle array removably attached thereto, the needle array having a body, a shroud movable with respect to the body between a rest position and one or more actuated positions, and an auto-lock assembly. Where the auto-lock assembly is adjustable between a locked configuration, where the shroud is not movable with respect to the body, and an unlocked configuration, where the shroud is movable with respect to the body, and where biasing the shroud from the rest position to the one or more actuated positions and back to the rest position adjusts the auto-lock from the unlocked configuration to the locked configuration.
Type:
Grant
Filed:
July 2, 2021
Date of Patent:
January 30, 2024
Assignee:
Inovio Pharmaceuticals
Inventors:
Beat Stadelmann, Stephen Kemmerrer, Alejandro Campillo-Agusti, Eduardo Ho, Nathan Lovell, Steven Masterson
Abstract: Provided herein is an immunogenic composition comprising a synthetic consensus antigen to Follicle Stimulating Hormone Receptor (FSHR) protein which is abundant in many ovarian cancer sub-types. Also disclosed herein is a method of treating a tumor associated pathology in a subject in need thereof, by administering the immunogenic composition to the subject.
Type:
Grant
Filed:
August 29, 2017
Date of Patent:
January 9, 2024
Assignees:
The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc., The Wistar Institute of Anatomy and Biology
Inventors:
David Weiner, Alfredo Perales Puchalt, Jian Yan, Anna Maria Slager
Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an anti-influenza-hemagglutinin synthetic antibody. The disclosure also provides a method of preventing and/or treating influenza in a subject using said composition and method of generation.
Type:
Grant
Filed:
May 5, 2017
Date of Patent:
December 26, 2023
Assignees:
The Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology, Inovio Pharmaceuticals, Inc.
Inventors:
David B. Weiner, Ami Patel, Jian Yan, Sarah Elliott
Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to an HIV antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an HIV infection in a subject using said composition and method of generation.
Type:
Grant
Filed:
March 27, 2018
Date of Patent:
December 19, 2023
Assignees:
The Wistar Institute of Anatomy and Biology, Inovio Pharmaceuticals, Inc.
Abstract: Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HPV39 E6E7 and HPV45 E6E7. Pharmaceutical composition, recombinant vaccines comprising DNA plasmid and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HPV are disclosed.
Type:
Grant
Filed:
January 5, 2021
Date of Patent:
December 19, 2023
Assignees:
The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
Abstract: The invention provides a vaccine comprising a nucleic acid molecule that encodes a dog telomerase reverse transcriptase (dTERT) antigen, as well as methods of using the vaccine to induce an immune response against a TERT and to treat cancer in a mammal.
Abstract: Disclosed herein is a vaccine comprising a Middle East Respiratory Syndrome coronavirus (MERS-CoV) antigen. The antigen can be a consensus antigen. The consensus antigen can be a consensus spike antigen. Also disclosed herein is a method of treating a subject in need thereof, by administering the vaccine to the subject.
Type:
Grant
Filed:
September 10, 2021
Date of Patent:
October 31, 2023
Assignees:
The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
Inventors:
David Weiner, Karuppiah Muthumani, Niranjan Y. Sardesai
Abstract: Provided herein are nucleic acid molecules encoding an HPV antigen. Also provided are vaccines against human papillomavirus (HPV) comprising the nucleic acids, methods of inducing immune responses, and methods for prophylactically and/or therapeutically immunizing individuals against recurrent respiratory papillomatosis (RRP). Pharmaceutical compositions, recombinant vaccines comprising DNA plasmid and live attenuated vaccines are disclosed as well as methods of inducing an immune response to treat or prevent RRP are disclosed.
Type:
Grant
Filed:
May 14, 2021
Date of Patent:
September 5, 2023
Assignee:
Inovio Pharmaceuticals, Inc.
Inventors:
Stephanie Ramos, Jewell Walters, Jian Yan, Anna Slager, Charles Reed, Kate Broderick
Abstract: Embodiments herein relate to the field of injections, for instance needle-free injections, and more specifically, to methods and apparatus for spring-driven intramuscular and intradermal injections. Provided in some embodiments are needle-free injectors adapted to deliver intradermal injections, as well as vial adaptors that are adapted to function as spacers when used with a needle-free injection device.
Abstract: A method and device for electroporating adipocytes in the adipose layer of tissue, where the device includes a frame, a first electrode coupled to the frame having a first contact surface, a second electrode coupled to the frame having a second contact surface, and where the first contact surf ace and the second contact surface define a treatment zone therebetween. The method including positioning a fold of tissue between the first and second electrodes such that the treatment zone formed between the two electrodes includes an adipose layer of tissue and no skeletal muscle.
Abstract: Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.
Type:
Grant
Filed:
February 25, 2021
Date of Patent:
May 30, 2023
Assignees:
Inovio Pharmaceuticals, Inc., The Wistar Institute of Anatomy and Biology
Inventors:
Jian Yan, Kate Broderick, David Weiner, Kar Muthumani, Ami Patel
Abstract: Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated WT1 antigen. Vectors, compositions and vaccines comprising one or more nucleic acid sequences that encode a mutated WT1 antigen are disclosed. Methods of treating an individual who has a WT1-expressing tumor and methods of preventing a WT1-expressing tumor are disclosed. Mutated WT1 antigen is disclosed.
Type:
Grant
Filed:
December 17, 2018
Date of Patent:
May 2, 2023
Assignees:
The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
Inventors:
David B. Weiner, Jian Yan, Jewell Walters
Abstract: A novel electroporation device for the delivery of vaccines that is both effective in generating a protective immune response and tolerable delivery to a subject (or near painless); and also methods of using same device to vaccinate a subject against a variety of infectious diseases and types of cancer in a near painless.
Type:
Grant
Filed:
March 1, 2011
Date of Patent:
January 31, 2023
Assignee:
Inovio Pharmaceuticals, Inc.
Inventors:
Kate Broderick, Jay McCoy, Stephen V. Kemmerrer, Feng Lin, Rune Kjeken
Abstract: An apparatus is provided for injecting a fluid into body tissue, the apparatus comprising: a hollow needle; and fluid delivery means, wherein the apparatus is adapted to actuate the fluid delivery means in use so as to automatically inject fluid into body tissue during insertion of the needle into the said body tissue.
Abstract: Disclosed herein are compositions comprising optimized consensus TERT antigens and methods for treating cancer and in particular immunogenic compositions that treat and provide protection against tumor.
Type:
Grant
Filed:
September 29, 2017
Date of Patent:
October 11, 2022
Assignees:
The Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology, Inovio Pharmaceuticals, Inc.
Abstract: Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated consensus PRAME antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a mutated consensus PRAME antigen are disclosed. Methods of treating a subject with a PRAME-expressing tumor and methods of preventing a PRAME-expressing tumor are disclosed. Mutated consensus PRAME antigen is disclosed.
Type:
Grant
Filed:
December 13, 2018
Date of Patent:
May 24, 2022
Assignee:
Inovio Pharmaceuticals, Inc.
Inventors:
Jian Yan, Anna Slager, Bradley Garman, Neil Cooch