Patents Assigned to INPROTHER APS
  • IMPROVED EXPRESSION OF SURFACE-DISPLAYED ANTIGENS
    Publication number: 20260295030
    Abstract: The present invention relates to a composition comprising a transfection agent and an mRNA which encodes at least a human endogenous retrovirus (HERV) envelope protein or an immunogenic part thereof with a mutation in the immune-suppressive domain (ISD) that reduces its immunosuppressive property. The present invention also relates to the use of this composition in the manufacture of medicaments and in therapeutic and prophylactic treatment.
    Type: Application
    Filed: April 22, 2024
    Publication date: October 1, 2026
    Applicant: INPROTHER APS
    Inventors: Anne-Marie Carola ANDERSSON, Peter Johannes HOLST, Emeline RAGONNAUD, Lasse NEUKIRCH
  • NUCLEIC ACIDS ENCODING HUMAN ENDOGENOUS RETROVIRUS K (HERV-K) ENVELOPE PROTEINS CONTAINING MODIFIED IMMUNOSUPPRESSIVE DOMAINS (ISD) AND USES THEREOF
    Publication number: 20260077031
    Abstract: A vaccine for use in the prophylaxis and/or treatment of a disease The present invention relates to an adenoviral vector capable of encoding a virus-like particle (VLP), said VLP displaying an inactive immune-suppressive domain (ISD). The vaccine of the invention shows an improved immune response from either of both of the response pathways initiated by CD4 T cells or CD8 T cells.
    Type: Application
    Filed: July 11, 2025
    Publication date: March 19, 2026
    Applicant: INPROTHER APS
    Inventors: Peter HOLST, Christian THIRION, Lasse NEUKIRCH
  • Nucleic acids encoding human endogenous retrovirus K (HERV-k) envelope proteins containing modified immunosuppressive domains (ISD) and uses thereof
    Patent number: 12390522
    Abstract: The present invention relates to an adenoviral vector capable of encoding a virus-like particle (VLP), said VLP displaying an inactive immune-suppressive domain (ISD). The vaccine of the invention shows an improved immune response from either of both of the response pathways initiated by CD4 T cells or CD8 T cells.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: August 19, 2025
    Assignee: INPROTHER APS
    Inventors: Peter Holst, Christian Thirion, Lasse Neukirch
  • VACCINE FOR USE IN THE PROPHYLAXIS AND/OR TREATMENT OF A DISEASE
    Publication number: 20250186579
    Abstract: A vaccine for use in the prophylaxis and/or treatment of a disease The present invention relates to an adenoviral vector capable of encoding a virus-like particle (VLP), said VLP displaying an inactive immune-suppressive domain (ISD). The vaccine of the invention shows an improved immune response from either of both of the response pathways initiated by CD4 T cells or CD8 T cells.
    Type: Application
    Filed: February 21, 2025
    Publication date: June 12, 2025
    Applicant: INPROTHER APS
    Inventors: Peter HOLST, Christian THIRION, Lasse NEUKIRCH
  • Vaccine for use in the prophylaxis and/or treatment of a disease
    Patent number: 12263214
    Abstract: The present invention relates to an adenoviral vector capable of encoding a virus-like particle (VLP), said VLP displaying an inactive immune-suppressive domain (ISD). The vaccine of the invention shows an improved immune response from either of both of the response pathways initiated by CD4 T cells or CD8 T cells.
    Type: Grant
    Filed: January 16, 2024
    Date of Patent: April 1, 2025
    Assignee: INPROTHER APS
    Inventors: Peter Holst, Christian Thirion, Lasse Neukirch
  • Vaccine for use in the prophylaxis and/or treatment of a disease
    Patent number: 12023377
    Abstract: The present invention relates to an adenoviral vector capable of encoding a virus-like particle (VLP), said VLP displaying an inactive immune-suppressive domain (ISD). The vaccine of the invention shows an improved immune response from either of both of the response pathways initiated by CD4 T cells or CD8 T cells.
    Type: Grant
    Filed: April 28, 2022
    Date of Patent: July 2, 2024
    Assignee: INPROTHER APS
    Inventors: Peter Holst, Christian Thirion, Lasse Neukirch
  • VACCINE FOR USE IN THE PROPHYLAXIS AND/OR TREATMENT OF A DISEASE
    Publication number: 20240148860
    Abstract: The present invention relates to an adenoviral vector capable of encoding a virus-like particle (VLP), said VLP displaying an inactive immune-suppressive domain (ISD). The vaccine of the invention shows an improved immune response from either of both of the response pathways initiated by CD4 T cells or CD8 T cells.
    Type: Application
    Filed: January 16, 2024
    Publication date: May 9, 2024
    Applicant: INPROTHER APS
    Inventors: Peter HOLST, Christian THIRION, Lasse NEUKIRCH
  • Vaccine for use in the prophylaxis and/or treatment of a disease
    Patent number: 11883487
    Abstract: The present invention relates to an adenoviral vector capable of encoding a virus-like particle (VLP), said VLP displaying an inactive immune-suppressive domain (ISD). The vaccine of the invention shows an improved immune response from either of both of the response pathways initiated by CD4 T cells or CD8 T cells.
    Type: Grant
    Filed: April 28, 2022
    Date of Patent: January 30, 2024
    Assignee: INPROTHER APS
    Inventors: Peter Holst, Christian Thirion, Lasse Neukirch
  • A VACCINE FOR USE IN THE PROPHYLAXIS AND/OR TREATMENT OF A DISEASE
    Publication number: 20230181716
    Abstract: The present invention relates to an adenoviral vector capable of encoding a virus-like particle (VLP), said VLP displaying an inactive immune-suppressive domain (ISD). The vaccine of the invention shows an improved immune response from either of both of the response pathways initiated by CD4 T cells or CD8 T cells.
    Type: Application
    Filed: August 30, 2019
    Publication date: June 15, 2023
    Applicant: INPROTHER APS
    Inventors: Peter HOLST, Christian THIRION, Lasse NEUKIRCH
  • VACCINE FOR USE IN THE PROPHYLAXIS AND/OR TREATMENT OF A DISEASE
    Publication number: 20220387580
    Abstract: The present invention relates to an adenoviral vector capable of encoding a virus-like particle (VLP), said VLP displaying an inactive immune-suppressive domain (ISD). The vaccine of the invention shows an improved immune response from either of both of the response pathways initiated by CD4 T cells or CD8 T cells.
    Type: Application
    Filed: April 28, 2022
    Publication date: December 8, 2022
    Applicant: INPROTHER APS
    Inventors: Peter HOLST, Christian THIRION, Lasse NEUKIRCH
  • VACCINE FOR USE IN THE PROPHYLAXIS AND/OR TREATMENT OF A DISEASE
    Publication number: 20220347291
    Abstract: The present invention relates to an adenoviral vector capable of encoding a virus-like particle (VLP), said VLP displaying an inactive immune-suppressive domain (ISD). The vaccine of the invention shows an improved immune response from either of both of the response pathways initiated by CD4 T cells or CD8 T cells.
    Type: Application
    Filed: April 28, 2022
    Publication date: November 3, 2022
    Applicant: INPROTHER APS
    Inventors: Peter HOLST, Christian THIRION, Lasse NEUKIRCH
  • Vaccine for use in the prophylaxis and/or treatment of a disease
    Patent number: 11351247
    Abstract: The present invention relates to an adenoviral vector capable of encoding a virus-like particle (VLP), said VLP displaying an inactive immune-suppressive domain (ISD). The vaccine of the invention shows an improved immune response from either of both of the response pathways initiated by CD4 T cells or CD8 T cells.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: June 7, 2022
    Assignee: INPROTHER APS
    Inventors: Peter Holst, Christian Thirion, Lasse Neukirch
  • A VACCINE FOR USE IN THE PROPHYLAXIS AND/OR TREATMENT OF A DISEASE
    Publication number: 20200330586
    Abstract: The present invention relates to an adenoviral vector capable of encoding a virus-like particle (VLP), said VLP displaying an inactive immune-suppressive domain (ISD). The vaccine of the invention shows an improved immune response from either of both of the response pathways initiated by CD4 T cells or CD8 T cells.
    Type: Application
    Filed: August 30, 2018
    Publication date: October 22, 2020
    Applicant: INPROTHER APS
    Inventors: Peter HOLST, Christian THIRION, Lasse NEUKIRCH