Abstract: Provided herein is a method for determining the temporal progression of a biological phenomenon which may affect a studied subject, the method including the steps of providing first data relative to biomarkers for the studied subject, the biomarkers being relative to the progression of the biological phenomenon, providing a numerical model, converting the first data into at least one point on the same Riemann manifold, and using a numerical model to determine a temporal progression for the biological phenomenon for the studied subject, the numerical model being a function in a Riemann manifold, the numerical model associating to values of biomarkers a temporal progression trajectory for the biological phenomenon and data relative to the dispersion of the progression trajectory for the biological phenomenon among a plurality of subjects, the numerical model being obtained by using a stochastic approximation in an expectation-maximization technique on data relative to biomarkers.

Abstract: Processing method for transforming a first surface into a second surface, according to which: a/ in a (k+1)th iteration step, for each couple comprising a first elementary surface and a second elementary surface transformed from the first elementary surface in iteration k, the projection of the second elementary surface on the plane of the first elementary surface is determined and a matrix (A) is defined for said couple, where (A)=pkt,(pt)?1 and pt=[pn+1?pi]i=1 to n, pkt,=[p?n+1,k?p?i,k]i=1 to n; b/ the second elementary surfaces obtained for the (k+1)th iteration are determined as those minimizing a function including at least the term Eshape—k+1=(B).

Abstract: A control device implantable in a human body—includes a control unit and at least one electrode, said control unit being connected to each electrode to control stimulation and/or measurement thereof. The control unit includes: a timing dock; a memory storing configuration data defined to enable configuration of each electrode correlated with identifiers; a memory storing program data describing a time profile correlated with identifiers; an executor activatable to send each electrode electric pulses corresponding to a predetermined program according to a predetermined electrode configuration, according to the clock; a sequencer arranged to receive an ordered plurality of pairs, each including an electrode configuration identifier and a program identifier, and selectively to activate the executor with the electrode and program configuration pairs denoted by the pairs of identifiers received as an input, according to the order thereof and the clock.

Abstract: The present invention relates to a method and to apparatus for measuring electric charge, in particular for measuring small electric charges which are present in rapid succession, as happens under the effect of radiation, ionizing particles, or from piezo-electric means.The apparatus comprises an amplifier (2) having high input impedance and a feedback network. The feedback network comprises at least one branch (24) connecting the output (6) of the amplifier (2) to an inverting input (21) thereof. Three switches (3,4,5) are so connected that either one of two of them (3,4) is capable of interrupting the transmission of an electrical signal via said at least one branch (24) of the feedback circuit. The portion of said branch (24) located between said switches includes electrical energy storing means (C.sub.2).