Abstract: A compound of formula (I) in which the dotted lines indicate the presence of at least one double bond; n=0 to 4; R3 and R4 are H, or when n=1, R3 and R4 can also form together a double bond between the carbon atoms, and m=0, 1 or 2, Z is CH or N or Z is C and —CHR3— is ?CH— linked by the double bond to cyclopentanone; or ?(?)m- is absent, and Z is NH, >N-alkyl, >N-phenyl, >N-benzyl or >N heteroaryl; R8 is alkyl, aryl or heteroaryl which can be optionally substituted; EWG represents an electron withdrawing group selected from the group comprising COOR, COSR, CONRR?, CN, COR, CF3, SOR, SO2R, SONRR?, SO2NRR?, NO2, halogen, heteroaryl; and the pharmaceutical salts and stereisomers thereof. The compounds of formula (I) are potent in the treatment of neurodegenerative diseases such as Alzheimer's disease.

Abstract: A two-part polyisocyanate/polyol composition, curable upon mixing of the two parts for molding casted products, which comprises: —a first polyisocyanate part A, liquid at mixing temperature, comprising at least one polyisocyanate compound A1 bearing at least three (3) isocyanate groups and having at least one isocyanurate cycle in its molecule and at least one diisocyanate compound A2; and—a second polyol part B comprising at least one diol compound B1.